型号：GM-J#009613 -Cryorecovery

应用：These Scnn1a-Tg3-Cre mice express Cre recombinase under the control of the Scnn1a (sodium channel, nonvoltage-gated 1 alpha) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues (including cortex, thalamus, midbrain, and cerebellum).

型号：GM-J#009610 -Cryorecovery

应用：Mice hemizygous for the BAC LRRK2 transgene "overexpress" wildtype human leucine-rich repeat kinase 2 (LRRK2) gene directed by the human LRRK2 promoter/enhancer regions on the BAC transgene. These BAC LRRK2 mice (also called WT-OX mice) are a control strain for the BAC LRRK2R1441G Parkinson's disease strain (Stock No. 009604).

型号：GM-J#009609 -Cryorecovery

应用：These transgenic mice express the human LRRK2*G2019S, leucine-rich repeat kinase 2, mutant, and may be useful in studying Parkinson's disease.

型号：GM-J#009606 -Cryorecovery

应用：Six2-TGCtg mice express an EGFPCre fusion protein directed to nephron progenitor population cap mesenchyme from the onset of metanephric kidney development by the Six2 (sine oculis-related homeobox 2 homolog (Drosophila)) promoter/enhancer regions within the ~181 kb BAC transgene. These Six2-TGCtg mice may be useful as fluorescent or Cre-lox tools for lineage-tracing/marking Six2-expressing cells for studying multipotent nephron progenitor cell populations throughout kidney organogenesis.

型号：GM-J#009604 -Cryorecovery

应用：In response to numerous reports questioning the hypokinetic phenotype of this strain, The Jackson Laboratory initiated behavioral testing on a cohort of 12 month old hemizygous FVB/N-Tg(LRRK2*R1441G)135Cjli/J and age matched controls. To date, we have been unable to validate the hypokinetic motor deficits reported for this strain. We have verified the transgene is expressed.

型号：GM-J#009600 -Cryorecovery

应用：This Six2GCE knock-in/knock-out allele was designed to both abolish Six2 gene function and express EGFP and creERT2 from the Six2 promoter/enhancer elements. While EGFP expression is observed in nephron progenitor population cap mesenchyme from the onset of metanephric kidney development, Cre-ERT2 fusion gene activity is inducible observed in the same cells only following tamoxifen administration. These Six2GCE mice may be useful for lineage-tracing/marking Six2-expressing cells for studying multipotent nephron progenitor cell populations throughout kidney organogenesis.

型号：GM-J#009585 -Cryorecovery

应用：These mice express the tamoxifen-inducible Cre-ERT2 fusion protein (Cre-ERT2) under the control of the promoter/enhancer regions surrounding the site where the enhancer trap transgene randomly inserted. These mice may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in brain tissues.

型号：GM-J#009584 -Cryorecovery

应用：These mice express the tamoxifen-inducible Cre-ERT2 fusion protein (Cre-ERT2) under the control of the promoter/enhancer regions surrounding the site where the enhancer trap transgene randomly inserted. These mice may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in brain tissues.

型号：GM-J#009583 -Cryorecovery

应用：These mice express the tamoxifen-inducible Cre-ERT2 fusion protein (Cre-ERT2) under the control of the promoter/enhancer regions surrounding the site where the enhancer trap transgene randomly inserted. These mice may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in brain tissues.

型号：GM-J#009582 -Cryorecovery

应用：These mice express the tamoxifen-inducible Cre-ERT2 fusion protein (Cre-ERT2) under the control of the promoter/enhancer regions surrounding the site where the enhancer trap transgene randomly inserted. These mice may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in brain tissues.