产品型号：GM-J#009352 -Cryorecovery

产品应用：These CDX2P9.5-G22Cre transgenic mice harbor a nuclear-localized Cre recombinase with 22 guanine nucleotide repeat between initiating methionine (ATG) codon and the remainder of the coding region altering the cre reading frame. Presumably, following a somatic mutation that results in some frameshift mutation(s) in the guanine nucleotide tract in a subset of somatic cells, resultant expression of a functional Cre recombinase is driven by a 9.5 kb human caudal type homeo box 2 (CDX2) promoter/enhancer sequence. These CDX2P9.5-G22Cre transgenic mice may be useful as a somatic mutation reporter strain and/or to generate conditional mutations in colorectal epithelial cells.