型号：GM-J#008883 -Cryorecovery

应用：These ROSA26-Syn-A53T mice allow cre-inducible expression of the familial Parkinson's disease-associated A53T missense mutant form of human alpha-synuclein (human A53T α-Syn or SYNA53T), and may be useful for studying the progressive dopaminergic neurodegeneration of Parkinson's disease and other synucleinopathies, Lewy bodies, and synaptic plasticity.

型号：GM-J#008875 -Available

应用：Heterozygous mice harbor an Lgr5-EGFP-IRES-creERT2 "knock-in" allele that both abolishes Lgr5 gene function and expresses EGFP and CreERT2 fusion protein. When these mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in the Lgr5-expressing cells of the offspring. These mice may be useful for lineage-tracing or marking Lgr5-expressing stem cells of the small intestine.

型号：GM-J#008870 -Cryorecovery

应用：These Hspa2-Cre mice have expression of Cre recombinase directed to the developing male germ cells by the mouse Hspa2 (heat shock protein 2 [Hsp70-2]) promoter. The Hspa2-Cre sequences of the transgene are flanked by Acrv1 (acrosomal vesicle protein 1 [SP-10]) insulator elements (which are believed to tether the Acrv1 gene to the nuclear matrix in somatic cells [preventing transcription]). When these transgenic mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination is expected to result in deletion of the floxed sequences in leptotene/zygotene spermatocytes of the male offspring. The donating investigator reports that expression of Hspa2-Cre may be "leaky" and recombination of loxP-flanked sequences can occur in some cells in somatic tissues. These Hspa2-Cre mice may be useful to generate conditional mutations for studying mammalian spermatocyte development, gametogenesis and meiosis.

型号：GM-J#008863 -Available

应用：The Tie2-Cre (Tek-Cre) transgene has the mouse endothelial-specific receptor tyrosine kinase (Tek or Tie2) promoter directing expression of Cre recombinase. These Tek-Cre transgenic mice are a Cre-lox tool useful for deletion of floxed sequences in endothelial cells during embryogenesis and adulthood. Cre recombinase activity is also detected in reproductive tissues (endometrium, ovary, testis, epididymis), as well as extraembryonic vascular system and yolk sac.

型号：GM-J#008861 -Cryorecovery

应用：These transgenic mice express a tamoxifen-inducible cre recombinase from the endogenous promoter/enhancer elements of the elastase 1 locus. When induced, cre activity is observed in Ela1 expressing pancreatic acinar cells; making this strain useful in fate mapping of pancreatic acinar cells.

型号：GM-J#008859 -Cryorecovery

应用：These mice are transgenic for the A53T mutation of the human SNCA (synuclein, alpha) gene under the control of a human THY1 (thymus cell antigen 1, theta) promoter. Hemizygotes are viable and fertile and develop a Parkinson-like phenotype upon aging. Hind limb paralysis due to loss of motor neurons and a resting tremor are initially seen at about eight months of age. No Lewy body-like pathology is noted. Cell death in the spinal cord (extensive) and brain are observed.

型号：GM-J#008852 -Cryorecovery

应用：These En2-cre line 22 transgenic mice (also called En2cre-22, En2cre line Tg22, or En2-cre tg-22) have the mouse engrailed 2 (En2) promoter/enhancer elements directing expression of Cre recombinase to a subset of En2-expressing cells; including the embryonic midbrain-hindbrain (mesencephalon-metencephalon) constriction region of the developing brain that gives rise to the posterior midbrain and medial cerebellum.

型号：GM-J#008851 -Cryorecovery

应用：These transgenic mice express a tamoxifen-inducible cre recombinase directed by the wingless-related MMTV integration site 1 (Wnt1) promoter/regulatory sequences. When induced, cre activity is observed in the Wnt1-expressing cells; including midbrain, developing neural tube, migrating neural crest cells and dopaminergic neuron populations.

型号：GM-J#008848 -Cryorecovery

应用：These 8030451F13Rik-Tg2-Cre (Mybpc1-Cre) express Cre recombinase under the control of the Mybpc1 (myosin binding protein C, slow-type; formerly called 8030451F13Rik) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in the cortex of the brain and hippocampus.

型号：GM-J#008847 -Cryorecovery

应用：These Msx2-CreERT transgenic mice have expression of a tamoxifen-inducible cre (Cre-ERT) directed to apical ectodermal ridge (AER) of the developing limb by the -0.5 kbp promoter region from mouse homeobox msh-like 2 locus (Msx2). When these Msx2-CreERT transgenic mice are bred with mice containing a loxP-flanked sequences, tamoxifen-inducible Cre-mediated recombination is expected to result in deletion of the floxed sequences in AER of the developing limb.