型号：GM-J#009107 -Cryorecovery

应用：Wnt-1/GAL4/cre-11 transgenic mice were created by co-injection of both the pWEXP2-GAL4 transgene (Wnt1-GAL4) and the pWEXP3C-cre transgene (Wnt1-Cre). Transgenic mice have the wingless-related MMTV integration site 1 (Wnt1) promoter/regulatory sequences directing expression of both Cre recombinase and the GAL4 transcriptional activator to midbrain and developing neural tube.

型号：GM-J#009103 -Cryorecovery

应用：These Wfs1-Tg3-CreERT2 mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Wfs1 (Wolfram syndrome 1 homolog (human)) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues (including cortex, hippocampus, striatum, thalamus and cerebellum).

型号：GM-J#009102 -Cryorecovery

应用：Mice harboring this mNF-H-cre transgene have nuclear localized-Cre recombinase expression directed primarily to cortex and hippocampus neurons coinciding the late stages of brain development by the mouse neurofilament-H gene promoter. These mice may be useful in generating conditional knockouts for neurobiological, neurodevelopmental, neuromuscular, amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), or aging studies involving the neurons of the brain and spinal cord.

型号：GM-J#009090 -Cryorecovery

应用：This transgenic strain carries a modified Slc6a3-parkin-Q311X (a FLAG-tagged mutant human parkin gene) BAC. These mice are useful for studying Parkinson's disease pathogenesis and neurodegeneration.

型号：GM-J#009074 -Cryorecovery

应用：These transgenic mice express nuclear-localizing Cre recombinase under the control of the mouse Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha; alpha-MHC) promoter. Cre recombinase expression is detected in a majority of cardiac myocytes.

型号：GM-J#009061 -Cryorecovery

应用：These mice harbor a Osr1eGFPCreERt2 (Osr1GCE) "knock-in" allele that both abolishes Osr1 (odd-skipped related 1 (Drosophila)) gene function and expresses EGFP and creERT2 from the Osr1 promoter/enhancer elements. While EGFP expression is observed in intermediate mesoderm and dorsal lateral plate mesoderm of developing embryos (~E8.5), Cre-ERT2 fusion gene activity is inducible; observed in the same cells only following tamoxifen administration. These Osr1GCE mice may be useful for lineage-tracing/marking Osr1-expressing cells for studying metanephric kidney development, as well as vascular, heart, and urogenital development.

型号：GM-J#009044 -Cryorecovery

应用：A loxP-flanked puromycin resistance/STOP cassette followed by a fusion of firefly luciferase and synthetic antigen peptide SIYRYYGL were introduced to the Gt(ROSA)26Sor (gene trap ROSA 26, Philippe Soriano) locus. After Cre activity, the recombined locus has high expression of Luciferase-SIY fusion protein. This mutant mouse strain may be useful in studies of immune response to a self-antigen or over-expressed tumor-associated antigen when used in combination with tumor-prone models.

型号：GM-J#009043 -Cryorecovery

应用：A loxP-flanked puromycin resistance/STOP cassette followed by a fusion of firefly luciferase and synthetic antigen peptide SIYRYYGL were introduced to the Gt(ROSA)26Sor (gene trap ROSA 26, Philippe Soriano) locus. After Cre activity, the recombined locus has high expression of Luciferase-SIY fusion protein. This mutant mouse strain may be useful in studies of immune response to a self-antigen or over-expressed tumor-associated antigen when used in combination with tumor-prone models.

型号：GM-J#008889 -Cryorecovery

应用：These ROSA26-Syn119 mice allow cre-inducible expression of the Syn119 C-terminally truncated mutation of human alpha-synuclein (human α-Syn119 or SynCT119; associated with familial Parkinson's disease), and may be useful for studying the progressive dopaminergic neurodegeneration of Parkinson's disease and other synucleinopathies, Lewy bodies, and synaptic plasticity.

型号：GM-J#008886 -Cryorecovery

应用：These ROSA26-Syn-E46K mice allow cre-inducible expression of the E46K missense mutant form of human alpha-synuclein (human E46K α-Syn or SYNE46K) associated with familial Parkinson's disease, dementia, and visual hallucinations, and may be useful for studying the progressive dopaminergic neurodegeneration of Parkinson's disease and other synucleinopathies, Lewy bodies, and synaptic plasticity.