型号：GM-J#012688 -Cryorecovery

应用：These mice express Cre-ERT2 fusion protein (Cre-ERT2) under the control of the promoter/enhancer regions surrounding the site where the enhancer trap transgene randomly inserted. These mice may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in brain tissues.

型号：GM-J#012646 -Cryorecovery

应用：In these mice endogenous gene function of the serine carboxypeptidase 1 (Scpep1) gene is replaced with a β-galactosidase (lacZ) gene. These mice may be useful for studying vascular remodeling after injury and vascular occlusive diseases.

型号：GM-J#012641 -Cryorecovery

应用：This transgenic cre strain (also called FSP1cre) may be useful for generating fibroblast specific-targeted mutants.

型号：GM-J#012621 -Cryorecovery

应用：These α3[5] mice contain a mutation designed to introduce 5 nucleotide mutations to exon 5 of mouse nicotinic acetylcholine receptor (nAChR) neuronal α3 subunit and a loxP-flanked neomycin (neo) resistance cassette upstream of exon 5. These mice may be useful for studying the pathological mechanisms of receptor assembly and trafficking in neurological and psychiatric disorders including Alzheimer's disease, Parkinson's disease, schizophrenia, and epilepsy, as well as drug addiction, response to pain, and nicotine induced behaviors.

型号：GM-J#012620 -Cryorecovery

应用：These mice carry the beta-lactoglobulin Cre (BLG-Cre) transgene, are homozygous for floxed exons 22-24 of the breast cancer 1 (Brca1) allele, and are heterozygous for p53 tumor-suppressor gene (Trp53) deficiency. This strain may be useful for studying human basal-like cancer and breast cancer, as well as providing a useful tool for testing new therapeutics.

型号：GM-J#012601 -Available

应用：Expression of Cre recombinase with enhanced green fluorescent protein (EGFP) in these knock-in mice is driven by the Lyve1 (lymphatic vessel endothelial hyaluronan receptor 1) promoter. When crossed with a strain carrying a floxed gene of interest this strain is useful for conditional ablation of genes in the lymphatic endothelium and studies of lymphatic development, function and lymphangiogenesis.

型号：GM-J#012588 -Cryorecovery

应用：THpPLAP transgenic mice have the rat tyrosine hydroxylase (TH) promoter directing expression of the human Placental Alkaline Phosphatase (ALPP or hPLAP) gene. These mice may be useful for visualizing DA cells, and correlating their physiological properties with their synaptic connections by use of microscopy, electrophysiology, and molecular biology, and for studying the pathophysiology of Parkinson's disease, and other neurodegenerative disorders.

型号：GM-J#012587 -Cryorecovery

应用：A CMV/beta actin (Z/AP) promoter located 2 kb 5' of the Igs1 (intergenic site, formerly Ubb) gene drives constitutive expression of a nuclear-localized beta-galactosidase/neomycin resistance protein reporter (NLS-beta-geo) in the absence of Cre-mediated recombination. When Cre-mediated recombination occurs in neurons, the amino terminal piece (tdTomato/TEVP, a 6xMyc epitope, a TEVP cleavage site) labels all axon and dendrites, and the carboxy-terminal portion (PSD95, GFP, 3xHA epitope) labels post-synaptic structures.

型号：GM-J#012586 -Available

应用：This BAC transgenic line expresses CreERT under the control of the Slc1a3 (solute carrier family 1 (glial high affinity glutamate transporter); GLAST) promoter. When crossed with a strain containing a loxP site flanked sequence, the offspring are useful for generating tamoxifen-induced, Cre-mediated targeted glia and neural progenitor cell-specific deletions. This strain is a useful tool in studies of neurodevelopment.

型号：GM-J#012570 -Cryorecovery

应用：Ai34D mice harbor a knock-in mutation of the Gt(ROSA)26Sor locus with a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Synaptophysin-tdTomato fusion gene. Following Cre-mediated removal of the STOP cassette, Synaptophysin-tdTomato expression is observed at synaptic termini in brain regions.