型号：GM-J#012906 -Cryorecovery

应用：The nestin-CreER transgene contains the rat nestin enhancer/hsp68 minimal promoter directing expression of a tamoxifen-inducible Cre recombinase (Cre-ERT1). When these nestin-CreER transgenic mice are bred with mice containing a loxP-flanked sequence, tamoxifen-inducible Cre-mediated recombination is expected to result in deletion of the floxed sequences in the Cre recombinase-expressing tissues of the offspring. These mice may be useful for studying embryonic and adult neurogenesis.

型号：GM-J#012887 -Not Available At Jax

应用：In 2014, The Jackson Laboratory Stock No. 012887 was confirmed to have the same expression pattern as GFAP-Cre line 73.12 (Stock No. 012886). Therefore, Stock No. 012887 was discontinued. To replace it, The Jackson Laboratory is offering the correctly-expressing GFAP-Cre line 77.6 mice from Dr. Michael Sofroniew to establish a new GFAP-Cre line 77.6 colony as Stock No. 024098.

型号：GM-J#012886 -Available

应用：This strain is undergoing recovery from cryopreserved stocks.

型号：GM-J#012859 -Cryorecovery

应用：These Neurog1457-Cre may be useful for generating conditional mutations in Neurog1 lineages in the central and peripheral nervous systems.

型号：GM-J#012849 -Available

应用：These GCE transgenic mice have a human glial fibrillary acidic protein (hGFAP) promoter sequence directing expression of a Cre-estrogen receptor (Cre-ERT2) fusion protein. When these transgenic mice are bred with mice containing a loxP-flanked sequence, tamoxifen-inducible Cre-mediated recombination is expected to result in deletion of the floxed sequences in the Cre recombinase-expressing tissues of the offspring.

型号：GM-J#012841 -Cryorecovery

应用：These GT.cre transgenic mice express Cre recombinase in cortical tubular epithelium of the kidney and may be useful for generating conditional mutations to study polycystic kidney disease and renal fibrosis.

型号：GM-J#012839 -Cryorecovery

应用：In Ox40-cre mice, the targeted mutation inserts an internal ribosome entry site (IRES)-Cre recombinase into exons 3 of the tumor necrosis factor receptor superfamily, member 4 (Tnfrsf4 or Ox40) locus, abolishing gene function. These mice are useful for inducing Cre-dependent genetic changes in OX40-expressing cells.

型号：GM-J#012837 -Available

应用：Lck-cre transgenic mice contain a Cre-recombinase gene driven by the distal promoter of the lymphocyte protein tyrosine kinase (Lck) gene. These mice are useful for studying the consequences of mutations induced after positive selection in the thymus.

型号：GM-J#012769 -Cryorecovery

应用：Thy1mγSN transgenic mice have the mouse thymus cell antigen 1 (Thy-1) promoter directing expression of the mouse γ-synuclein (Sncg) gene. These mice may be useful for studying the pathophysiology of Parkinson's disease, and other neurodegenerative disorders.

型号：GM-J#012735 -Cryorecovery

应用：The Ai35D (or Ai35Δneo) allele has a floxed-STOP cassette preventing transcription of the downstream Arch-GFP fusion gene. Exposure to Cre recombinase that deletes the STOP cassette results in Arch-GFP expression. These Ai35D mice are useful for optogenetic studies to express an inhibitory opsin that effectively silences the activity of cortical neurons (and perhaps other excitable cell types such as muscle cells and immune cells).