型号：GM-J#012570 -Cryorecovery

应用：Ai34D mice harbor a knock-in mutation of the Gt(ROSA)26Sor locus with a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Synaptophysin-tdTomato fusion gene. Following Cre-mediated removal of the STOP cassette, Synaptophysin-tdTomato expression is observed at synaptic termini in brain regions.

型号：GM-J#012569 -Cryorecovery

应用：Ai32 mice express an improved channelrhodopsin-2/EYFP fusion protein following exposure to Cre recombinase. These mice can be used in optogenetic studies for rapid in vivo activation of excitable cells by illumination with blue light (450-490 nm).

型号：GM-J#012567 -Cryorecovery

应用：Ai27D mice express an improved channelrhodopsin-2/tdTomato fusion protein following exposure to Cre recombinase. These mice can be used in optogenetic studies for rapid in vivo activation of excitable cells by illumination with blue light (450-490 nm).

型号：GM-J#012476 -Cryorecovery

应用：Tamoxifen-induced, Cre-mediated targeted deletions in tissues such as myogenic progenitor cells and adult myogenic satellite cells can be created upon crossing these Pax7CE mutant mice with a strain carrying a floxed gene of interest.

型号：GM-J#012467 -Cryorecovery

应用：These BAC Lrrk2-G2019S mice express a mutant form of mouse leucine-rich repeat kinase 2 (Lrrk2-G2019S) associated with autosomal dominant, late-onset Parkinson's disease directed by the endogenous Lrrk2 promoter/enhancer regions on the BAC transgene. These mice have reduced striatal dopamine content and may be useful for studying Parkinson's disease pathogenesis and neurodegeneration elicited by the dominant toxic effects of mutant LRRK2-G2019S expression.

型号：GM-J#012466 -Cryorecovery

应用：These FLAG-Lrrk2-WT mice express a wild-type mouse leucine-rich repeat kinase 2 (Lrrk2) gene directed by its endogenous promoter/enhancer regions on a BAC transgene. These mice may be useful for studying normal function of LRRK2 function and the pathogenesis of Parkinson's disease.

型号：GM-J#012464 -Cryorecovery

应用：The Foxd1GCE allele expresses an eGFPCreERT2 fusion protein (EGFP and creERT2 fusion protein) from the Foxd1 promoter/enhancer elements. These mice may be useful for studying therapeutic strategies directly targeting pericyte differentiation in vivo and may productively impact fibrotic kidney disease.

型号：GM-J#012463 -Cryorecovery

应用：The Foxd1tm1(GFP/cre)Amc (or FoxD1GC) allele expresses an eGFPCre fusion protein from the Foxd1 promoter/enhancer elements. These mice may be useful for studying therapeutic strategies directly targeting pericyte differentiation in vivo and may productively impact fibrotic kidney disease.

型号：GM-J#012462 -Cryorecovery

应用：SF1-Cre transgenic mice have Cre recombinase expression detected in steroidogenic factor-1 (SF1)-positive neurons in the ventromedial hypothalamic nucleus as well as pituitary, gonad, and adrenal tissue. These mice may be useful for generating tissue specific-targeted mutants for studies of the subset of SF1-positive neurons, obesity, metabolic and energy homeostasis, and appetite control/satiety.

型号：GM-J#012453 -Cryorecovery

应用：Homozygous Lrrk2 knock-out mice may be useful for studying Parkinson's disease pathogenesis and neurodegeneration, as the deletion of Lrrk2 promotes the extension of neurites and decreases the accumulation of alpha-synuclein aggregates.