型号:GM-J#013536 -Cryorecovery
应用:In this strain, codon 103 in exon 3 of the endogenous mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1 or Jip1) gene is mutated from a Threonine (ACT) to an Alanine (GCC). These mice may be useful for studying MAP kinase signaling pathways and activation of JNK in response to metabolic stress.
型号:GM-J#013535 -Cryorecovery
应用:In this knockout strain, a neomycin resistance cassette replaces exon 3 of the endogenous mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1 or Jip1) gene. These mice may be useful for studying MAP kinase signaling pathways and stress-induced activation of JNK.
型号:GM-J#013251 -Cryorecovery
应用:These EIIa-Cre transgenic mice express Cre recombinase under the control of the adenovirus EIIa promoter. When crossed with a strain containing loxP site-flanked sequences, Cre-mediated recombination occurs in a wide range of tissues, including germ cells that transmit the genetic alteration to progeny.
型号:GM-J#013234 -Cryorecovery
应用:CD4-Cre transgenic mice contain CD4 enhancer, promoter and silencer sequences driving the expression of a Cre recombinase gene. These mice may be useful for generating conditional mutations in CD4-expressing tissues.
型号:GM-J#013233 -Cryorecovery
应用:These CD11c-Cre-GFP transgenic mice may be useful in immunological studies, specifically Type 1 Diabetes, utilizing Cre-lox technology or fluorescent protein expression in dendritic cells.
型号:GM-J#013148 -Available
应用:Cre recombinase expression in hemizygous Pdgfra-cre mice is directed to Muller glial cells by endogenous promoter/enhancer elements of the Pdgfra gene. These mice may be useful for generating conditional mutations for studying retinal degeneration, retinitis pigmentosa, macular degeneration, and the role of Muller glial cells in progressive neuronal cell death.
型号:GM-J#013110 -Cryorecovery
应用:Mutant mice exhibit hind limb atrophy and a progressive decrease in body weight leading to paralysis and premature death.
型号:GM-J#013050 -Cryorecovery
应用:These knock-in mice contain a mutation designed to replace gene function of the endogenous mouse Pink1 gene with the loss-of-function mutation, G309D, and a loxP-flanked neomycin resistance cassette (neo). These mice show increasing mitochondrial dysfunction resulting in impaired neural activity similar to PD, in absence of overt neuronal death.
型号:GM-J#013048 -Cryorecovery
应用:The Etv1-CreERT2 knock-in allele was designed to both abolish ets variant gene 1 (Etv1) gene function and direct CreERT2 fusion protein expression to ER81 positive neurons (including Layer5 pyramidal neurons) by the endogenous Etv1 promoter/enhancer elements. Cre-ERT2 fusion gene activity is inducible by tamoxifen administration.
型号:GM-J#013044 -Available Now
应用:Sst-IRES-Cre knock-in mice express Cre recombinase in somatostatin-expressing neurons. These mice may be useful in studying dendritic inhibitory interneurons such as Martinotti cells and Oriens-Lacunosum-Moleculare cells.