型号：GM-J#012450 -Cryorecovery

应用：These hemizygous transgenic mice carry a human synuclein (alpha-syn) gene, SNCA, regulated by a tetracycline operator (tetO). When mated to a mutant strain expressing tetracycline-controlled transactivator protein (tTA), expression of SNCA protein may be regulated with the tetracycline analog doxycycline (dox) in the double mutant offspring. These mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration elicited by the toxic effects of aggregation and somatic accumulation of SNCA.

型号：GM-J#012449 -Cryorecovery

应用：These hemizygous transgenic mice carry a human leucine-rich repeat kinase 2 gene, LRRK2, regulated by a tetracycline operator (tetO). When mated to a mutant strain expressing tetracycline-controlled transactivator protein (tTA), expression of LRRK2 protein may be regulated with the tetracycline analog doxycycline (dox) in the double mutant offspring. These mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration.

型号：GM-J#012446 -Cryorecovery

应用：These transgenic mice express the mutant human LRRK2 sequence, 6055G->A transition (G2019S), and may be useful in studies of Parkinson's disease.

型号：GM-J#012445 -Cryorecovery

应用：These transgenic mice express the human LRRK2 gene and may be useful in studies of Parkinson's disease.

型号：GM-J#012444 -Cryorecovery

应用：This LRRK2 knock-out targeted mutation strain exhibits enhanced neuritic outgrowth and may be useful in studies of dendritic neuronal arborization and Parkinson's disease.

型号：GM-J#012442 -Cryorecovery

应用：These transgenic mice carry a humanized synuclein (alpha-syn) mutant (SNCA*A53T) gene regulated by a tetracycline operator (tetO). When mated to a mutant strain expressing tTA, expression of SNCA*A53T protein may be regulated with the tetracycline analog doxycycline in the double mutant offspring.

型号：GM-J#012441 -Cryorecovery

应用：These hemizygous transgenic mice carry a humanized leucine-rich repeat kinase 2 mutant gene, LRRK2*G2019S, regulated by a tetracycline operator (tetO). When mated to a mutant strain expressing tetracycline-controlled transactivator protein (tTA), expression of LRRK2*G2019S protein may be regulated with the tetracycline analog doxycycline (dox) in the double mutant offspring. These mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration elicited by the dominant toxic effects of mutant LRRK2*G2019S expression.

型号：GM-J#012433 -Cryorecovery

应用：This HSA-rtTA/TRE-Cre mutant mouse strain may be useful for generating tissue specific-targeted mutants that would be useful in studying gene function in skeletal muscle, and is especially useful for studying steroid and hormone regulation in skeletal muscle and muscle/motorneuron interactions.

型号：GM-J#012429 -Cryorecovery

应用：The R26NZG targeting vector contains a loxP-flanked PGK-Neo-4x polyA STOP cassette, FRT-flanked a nuclear localized β-galactosidase (nlslacZ)-3x polyA, and enhanced green fluorescent protein (EGFP)-1x polyA. These mice may be useful as a Cre mediated reporter or a FLP reporter when expressed in cells/tissues where the expression patterns of the individual promoters driving CRE recombinase and FLP recombinase overlap.

型号：GM-J#012373 -Cryorecovery

应用：These Hoxb1 Cre recombinase knock-in mice may be useful for generating mutations to study fate mapping of cell lineages derived from rhombomere 4 (r4) of the hindbrain.