型号：GM-J#026975 -Cryorecovery

应用：These edn2-iCre transgenic mice have the mouse endothelin 2 (Edn2) promoter driving codon optimized iCre recombinase expression in the epidermis, ovary (capsule, stromal cells, corpora lutea, granulosa cells), testicular interstitium, coagulation gland (anterior prostate), and preputial gland.

型号：GM-J#026944 -Cryorecovery

应用：The RC::L-DTA allele has a cre-dependent FLEx switch containing an eGFP sequence and an inverted tox176 attenuated diphtheria toxin subunit alpha gene (DTA*G128D) that are uniquely flanked/separated by inward-facing lox sites (both lox2272 and loxP). Widespread eGFP fluorescence is observed in the absence of Cre recombinase. Subsequent exposure to Cre recombinase that places the DTA*G128D into the proper orientation for expression results in ablation of those cells.

型号：GM-J#026943 -Cryorecovery

应用：RC::L-hM3Dq is a Gq-coupled DREADD allele with a cre-dependent FLEx switch containing an eGFP sequence and an inverted hM3Dq/mCherry/2ACT88 fusion protein. Upon exposure to Cre recombinase, the widespread and robust eGFP fluorescence may be replaced with somatodendritic hM3Dq/mCherry expression. The hM3Dq DREADD induces the canonical Gq pathway (depolarization/activation) specifically following administration of its pharmacologically inert ligand (CNO). The RC::L-hM3Dq allele and its derivatives permit chemogenetic/pharmacogenetic activation defined by Cre recombinase expression.

型号：GM-J#026942 -Available

应用：RC::FL-hM3Dq is a dual recombinase-responsive Gq-coupled DREADD allele with a frt-flanked STOP and a cre-dependent FLEx switch containing an eGFP sequence and an inverted hM3Dq/mCherry/2ACT88 fusion protein. Flp-recombinase results in widespread, robust eGFP fluorescence, and further exposure to Cre recombinase may replace eGFP expression with somatodendritic hM3Dq/mCherry expression. The DREADD hM3Dq induces the canonical Gq pathway (depolarization/activation) specifically following administration of its pharmacologically inert ligand (CNO). The RC::FL-hM3Dq allele and its derivatives permit chemogenetic/pharmacogenetic activation of an intersectional subpopulation defined by overlap of Flp and Cre recombinase expression.

型号：GM-J#026932 -Available

应用：The RC::FLTG dual-recombinase responsive indicator allele is designed with a frt-flanked STOP and loxP-flanked tdTomato::STOP all preventing transcription of eGFP. Flp recombinase results in high tdTomato fluorescence, and further exposure to Cre recombinase results in robust eGFP fluorescence. The RC::FLTG allele and its derivatives are useful for fluorescent labeling of cells/tissues in embryonic or adult mice. These mice allow intersectional genetic fate mapping of different cell subpopulations defined by the overlap of two gene expression domains.

型号：GM-J#026931 -Available For Registering Interest

应用：This strain is currently unavailable due to replenishing of cryopreserved stocks.  Interested customers can register interest.

型号：GM-J#026930 -Cryorecovery

应用：The RC::RFLTG triple-recombinase responsive indicator allele is designed with a rox-flanked STOP, frt-flanked STOP and loxP-flanked tdTomato::STOP all preventing transcription of eGFP. Dre- and FLP-recombinase result in high tdTomato fluorescence, and further exposure to Cre recombinase results in robust eGFP fluorescence. The RC::RFLTG allele and its derivatives (e.g., dual-recombinase responsive and single-recombinase responsive) are useful for fluorescent labeling of cells/tissues in embryonic or adult mice. These mice allow intersectional genetic fate mapping of different cell subpopulations defined by the overlap of three gene expression domains.

型号：GM-J#026925 -Available

应用：K19CreERT knock-in/knock-out mice may be useful for applications requiring tamoxifen-induced deletion of floxed sequences in KRT19-expressing epithelial cells.

型号：GM-J#026880 -Cryorecovery

应用：These Nkx2-2:Cre-EGFP Knockin/knockout mice may have applications in studies requiring conditional gene manipulation or lineage fate mapping in the CNS, pancreas and intestine.

型号：GM-J#026863 -Cryorecovery

应用：These Gt(ROSA)26Sortm1Sor targeted mutant mice carry a loxP flanked neo cassette upstream of a β-galactosidase (lacZ) sequence. Removal of the neo cassette by cre recombination results in lacZ expression in cre-expressing tissues of the offspring. These mutant mice may be used as a Cre-reporter strain; to test the tissue/cellular expression pattern of cre transgenic mice.