型号：GM-J#027012 -Cryorecovery

应用：These Foxj1CreERT2::GFP knock-in/knock-out mice express GFP and tamoxifen inducible Cre recombinase in epithelial cells with motile cilia. They are suitable for use in applications related to the study of ciliogenesis, as well as lineage tracing of Foxj1 expressing cells.

型号：GM-J#026975 -Cryorecovery

应用：These edn2-iCre transgenic mice have the mouse endothelin 2 (Edn2) promoter driving codon optimized iCre recombinase expression in the epidermis, ovary (capsule, stromal cells, corpora lutea, granulosa cells), testicular interstitium, coagulation gland (anterior prostate), and preputial gland.

型号：GM-J#026944 -Cryorecovery

应用：The RC::L-DTA allele has a cre-dependent FLEx switch containing an eGFP sequence and an inverted tox176 attenuated diphtheria toxin subunit alpha gene (DTA*G128D) that are uniquely flanked/separated by inward-facing lox sites (both lox2272 and loxP). Widespread eGFP fluorescence is observed in the absence of Cre recombinase. Subsequent exposure to Cre recombinase that places the DTA*G128D into the proper orientation for expression results in ablation of those cells.

型号：GM-J#026943 -Cryorecovery

应用：RC::L-hM3Dq is a Gq-coupled DREADD allele with a cre-dependent FLEx switch containing an eGFP sequence and an inverted hM3Dq/mCherry/2ACT88 fusion protein. Upon exposure to Cre recombinase, the widespread and robust eGFP fluorescence may be replaced with somatodendritic hM3Dq/mCherry expression. The hM3Dq DREADD induces the canonical Gq pathway (depolarization/activation) specifically following administration of its pharmacologically inert ligand (CNO). The RC::L-hM3Dq allele and its derivatives permit chemogenetic/pharmacogenetic activation defined by Cre recombinase expression.

型号：GM-J#026942 -Available

应用：RC::FL-hM3Dq is a dual recombinase-responsive Gq-coupled DREADD allele with a frt-flanked STOP and a cre-dependent FLEx switch containing an eGFP sequence and an inverted hM3Dq/mCherry/2ACT88 fusion protein. Flp-recombinase results in widespread, robust eGFP fluorescence, and further exposure to Cre recombinase may replace eGFP expression with somatodendritic hM3Dq/mCherry expression. The DREADD hM3Dq induces the canonical Gq pathway (depolarization/activation) specifically following administration of its pharmacologically inert ligand (CNO). The RC::FL-hM3Dq allele and its derivatives permit chemogenetic/pharmacogenetic activation of an intersectional subpopulation defined by overlap of Flp and Cre recombinase expression.

型号：GM-J#026932 -Available

应用：The RC::FLTG dual-recombinase responsive indicator allele is designed with a frt-flanked STOP and loxP-flanked tdTomato::STOP all preventing transcription of eGFP. Flp recombinase results in high tdTomato fluorescence, and further exposure to Cre recombinase results in robust eGFP fluorescence. The RC::FLTG allele and its derivatives are useful for fluorescent labeling of cells/tissues in embryonic or adult mice. These mice allow intersectional genetic fate mapping of different cell subpopulations defined by the overlap of two gene expression domains.

型号：GM-J#026931 -Available For Registering Interest

应用：This strain is currently unavailable due to replenishing of cryopreserved stocks.  Interested customers can register interest.

型号：GM-J#026930 -Cryorecovery

应用：The RC::RFLTG triple-recombinase responsive indicator allele is designed with a rox-flanked STOP, frt-flanked STOP and loxP-flanked tdTomato::STOP all preventing transcription of eGFP. Dre- and FLP-recombinase result in high tdTomato fluorescence, and further exposure to Cre recombinase results in robust eGFP fluorescence. The RC::RFLTG allele and its derivatives (e.g., dual-recombinase responsive and single-recombinase responsive) are useful for fluorescent labeling of cells/tissues in embryonic or adult mice. These mice allow intersectional genetic fate mapping of different cell subpopulations defined by the overlap of three gene expression domains.

型号：GM-J#026925 -Available

应用：K19CreERT knock-in/knock-out mice may be useful for applications requiring tamoxifen-induced deletion of floxed sequences in KRT19-expressing epithelial cells.

型号：GM-J#026880 -Cryorecovery

应用：These Nkx2-2:Cre-EGFP Knockin/knockout mice may have applications in studies requiring conditional gene manipulation or lineage fate mapping in the CNS, pancreas and intestine.