型号：GM-J#027406 -Cryorecovery

应用：hCD2-cre mice may be useful for generating conditional mutations in mature CD4+ and CD8+ T cells.

型号：GM-J#027400 -Cryorecovery

应用：These R4Ag11 mice express nuclear-localized Cre recombinase from the mouse Camk2a promoter in the adult brain, with high levels in the forebrain.

型号：GM-J#027310 -Cryorecovery

应用：These R1Ag5 (R1ag#5) mice express nuclear-localized Cre recombinase from the mouse Camk2a promoter in the adult brain, with high levels in all forebrain structures, and moderate levels in the cerebellum as well as testis.

型号：GM-J#027235 -Cryorecovery

应用：The tamoxifen-inducible Notch1 activation-dependent reporter knock-in allele, N1IP::CreERT2, has the endogenous Notch1 intracellular domain (NICD1) replaced with a 6xMyc-tagged, tamoxifen-inducible Cre recombinase (6mtCreERT2). Similar to the N1IP::CreLO allele, this N1IP::CreERT2 allele is predominantly expressed in cells in which moderate-to-high levels of sustained Notch activity or repeated activation cycles are known to occur (e.g., endothelium), with the added benefit that Cre recombinase activity is tamoxifen-inducible.

型号：GM-J#027234 -Cryorecovery

应用：The high-activity Notch1 activation-dependent reporter knock-in allele, N1IP::CreHI, has the endogenous Notch1 intracellular domain (NICD1) replaced with a nuclear-localized Cre recombinase. Compared to N1IP::CreLO, this N1IP::CreHI allele has significantly improved sensitivity with five- to ten-fold increase in Cre activity. This improved sensitivity allows users to label cells experiencing moderate-to-lower Notch activation thresholds; including most cells/tissues known to utilize Notch1 during their development and/or maintenance.

型号：GM-J#027214 -Cryorecovery

应用：These TrkBCreER mutant mice express Cre-ERT2 from the mouse Ntrk2 promoter. Endogenous NTRK2 expression is knocked out. Treatment with 4-hydroxytamoxifen (OHT) enables the Cre-mediated excision of introduced floxed sequences in dorsal root ganglion neurons.

型号：GM-J#027205 -Cryorecovery

应用：These Nms-iCre mice express codon-improved Cre recombinase in a subset of Nms-expressing neurons in the suprachiasmatic nucleus and may be useful in studying circadian rhythms and behavior.

型号：GM-J#027178 -Cryorecovery

应用：These DAT-PF-tTA mice conditionally express tetracycline responsive transactivator (tTA) in dopamine neurons from the mouse Slc6a3 (DAT) promoter. A “PF” (tetO-tTA) positive feedback cassette is incorporated in the construct to amplify tTA expression. Homozygotes have little or no endogenous SLC6A3/DAT expression and show growth retardation. These mice may be useful for studying gene function in dopaminergic neurons, such as drug addiction, Parkinson's disease and Attention Deficit-Hyperactivity Disorder (ADHD).

型号：GM-J#027116 -Cryorecovery

应用：CD19creERT2 mice express tamoxifen-inducible Cre recombinase under the direction of the Cd19 promoter in B lymphocytes.

型号：GM-J#027039 -Cryorecovery

应用：These Grem1-creERT mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Grem1 promoter. When bred with mice containing loxP-flanked sequences, tamoxifen-inducible Cre-mediated recombination will result in deletion of the floxed sequences in the Grem1-expressing cells of the offspring. These mice may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in bone marrow osteochondroreticular stem cells (skeletal stem cells), and intestinal reticular stem cells.