型号：GM-J#026512 -Cryorecovery

应用：TPOCreER transgenic mice express Cre-ERT2 under the direction of the human thyroid peroxidase promoter. They are useful for applications requiring tamoxifen-induced deletion of floxed sequences in the thyroid.

型号：GM-J#026294 -Cryorecovery

应用：ReaChR protein (a red-shifted channelrhodopsin) was tagged with mCitrine fluorescent protein and placed under the conditional control of the Gt(ROSA)26Sor promoter. Excision of a single loxP- flanked stop cassette enables fluorescent expression. As an optogenetic tool, this strain is useful for the selective activation and mapping of neuron populations.

型号：GM-J#026293 -Cryorecovery

应用：These ROSA26-LRRK2 (R1441C) mice allow cre-inducible expression of the familial Parkinson's disease-associated R1441C missense mutant form of LRRK2, and may be useful for studying Parkinson's disease pathogenesis and neurodegeneration.

型号：GM-J#026266 -Cryorecovery

应用：cre expression in these mice is controlled by regulatory sequences from the mouse zona pellucida 3 (Zp3) promoter, which normally directs expression exclusively in the growing oocyte prior to the completion of the first meiotic division. This strain would be useful for deleting a floxed sequence specifically in the female germ line.

型号：GM-J#026262 -Cryorecovery

应用：Ai92(TITL-YCX2.60)-D (also called Ai92D) mice are a Cre/Tet-dependent, fluorescent calcium indicator line, created by targeted insertion of floxed-STOP-YCX2.60 at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassettes by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of a FRET-based Ca2+ sensor with expanded dynamic range (YCX2.60). Following subsequent calcium binding (such as neuronal activation), robust yellow fluorescence and diminished cyan fluorescence is observed.

型号：GM-J#026260 -Cryorecovery

应用：Ai85(TITL-iGluSnFr)-D (also called Ai85D) mice are a Cre/Tet-dependent, fluorescent glutamate indicator line, created by targeted insertion of floxed-STOP-iGluSnFr at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassette by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of iGluSnFr, an intensity-based glutamate-sensing fluorescent reporter that is fast and sensitive. Increased GFP fluorescence is observed following subsequent glutamate binding (such as excitatory synaptic activity).

型号：GM-J#026220 -Available

应用：The CAG-LSL-Gq-DREADD allele (formerly called R26-LSL-Gq-DREADD) allows Cre recombinase-inducible expression of a CAG promoter-driven HA-hM3Dq-pta-mCitrine. Following cre-mediated removal of an upstream floxed-STOP cassette, expression of HA-tagged hM3Dq and mCitrine yellow fluorescent protein is observed. hM3Dq is a mutant G protein-coupled receptor (GPCR) that induces the canonical Gq pathway specifically following administration of the pharmacologically inert molecule clozapine-N-oxide (CNO). These CAG-LSL-Gq-DREADD mice may be useful for chemogenetic/pharmacogenetic studies to express an activating DREADD that effectively induces firing of neurons.

型号：GM-J#026219 -Available

应用：R26-LSL-Gi-DREADD mice were designed to have Cre recombinase-inducible expression of a CAG promoter-driven HA-hM4Di-pta-mCitrine from the Gt(ROSA)26Sor locus. Following Cre-mediated removal of an upstream floxed-STOP cassette, higher expression levels of HA-tagged hM4Di and mCitrine yellow fluorescent protein is observed. See Important Note regarding expression levels before Cre.

型号：GM-J#026191 -Cryorecovery

应用：Kcnk9f/f floxed mice may be useful for studying pH sensitivity and chemosensitivity in respiratory neurons.

型号：GM-J#026092 -Cryorecovery

应用：Cre-mediated excision of a floxed exon 19-20/neomycin stop cassette enables expression of functional mVenus-labeled PSD95 (DLG4) synaptic protein without overexpression in an in vivo setting.