产品型号：GM-J#031570 -Cryorecovery

产品应用：Ai170(TIT2L-ASAP2s-Kv-ICL-tTA2)-D (or Ai170D) mice are a Cre/Tet-dependent, voltage-sensitive, fluorescent line for neuronal soma and proximal dendrites - created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Exposure to Cre recombinase removes both STOP cassettes - resulting in expression of tTA2 and ASAP2s-Kv (highly-sensitive green fluorescent voltage indicator with Kv2.1-tag). ASAP2s-Kv expression may then be diminished by doxycycline. Ai170D mice may be useful for in vivo imaging of voltage dynamics in soma and proximal dendrites.