型号：GM-J#035208 -Cryorecovery

应用：hMPO (MPOG) transgenic mice express the intact human myeloperoxidase (MPO) gene bearing a -463G promoter polymorphism, along with introns and flanking regions. This strain is useful in studies of human MPO involvement in models of inflammatory and neurodegenerative diseases, as well as cancer.

型号：GM-J#035186 -Cryorecovery

应用：In these 5-HT3A cKO mice, exon 2 of the mouse Htr3a (5-hydroxytryptamine (serotonin) receptor 3A; also called 5-HT3A) gene was replaced by a cassette consisting of two versions of exon 2: FLP-mediated recombination converts it randomly into HA-mVenus tagged exon 2 or FLAG tagged exon 2. Cre-mediated recombination is anticipated to result in deletion of exon 2 and a knock-out of the gene (not yet confirmed - April, 2020). This is a tool mouse line that will be useful for the community for identification of 5HT3A-receptor positive interneurons.

型号：GM-J#035178 -Cryorecovery

应用：HA-RARalpha KI knock-in mice express hemagglutinin-tagged mouse RARA (retinoic acid receptor, alpha) protein. Cre recombinase-mediated excision of floxed exons 4 and 5 results in the production of hemagglutinin-tagged RARA protein lacking the DNA binding domain.

型号：GM-J#035169 -Available

应用：The inducible KPC:APC mouse model of KRAS mutated colorectal cancer combines the oncogenic conditional KrasG12D allele, the conditional Apcfl allele and a tamoxifen inducible Cre recombinase (CDX2-Cre-ERT2) with cre expression in adult epithelium of the distal intestinal tract. Mice develop malignant colonic tumors 25-30 days post tamoxifen induction.

型号：GM-J#035136 -Cryorecovery

应用：Cre-inducible-Mps1-Knock-in-TA (CiMKiTA) mice carry a Cre-inducible point mutation (T649A) in exon 17 of the Ttk protein kinase (Ttk) gene, expression of which is blocked by the presence of a loxP-flanked cDNA cassette encoding exons 17-22 and a stop codon. This mutation results in a mutant protein similar to that found in human cell lines with a mild chromosomal instability (CIN) phenotype. This strain may be useful when studying oncogenic potential due to the degree and site of chromosomal instability.

型号：GM-J#035093 -Cryorecovery

应用：Krt6-CreERmice have a CRISPR/Cas9 generated insertion of an IRES-Cre/ERT2-SV40pA cassette inserted into the 3' UTR of the Krt6a gene, without disrupting endogenous gene expression. These mice may be used to generate tamoxifen-induced conditional mutations for studying gain-or-loss of function and/or fate mapping related to KRT6A expression during stem cell differentiation.

型号：GM-J#035092 -Available

应用：Sox9-CreER mice have a CRISPR/Cas9 generated insertion of an IRES-Cre/ERT2-SV40pA cassette inserted into the 3' UTR of the Sox9 gene, without disrupting endogenous gene expression. These mice may be used to generate tamoxifen-induced conditional mutations for studying gain-or-loss of function and/or fate mapping related to SOX9 expression during stem cell differentiation.

型号：GM-J#035046 -Cryorecovery

应用：NK1R-CreER knock-in/knock-out mice have the endogenous tachykinin receptor 1 promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice are a Cre-lox tool allowing inducible Cre recombination in Tacr-expressing cells/tissues (including neurons of the amygdala, hypothalamus, cortex, and spinal cord), and may be useful in studying Substance P signaling, inflammatory responses, and pain.

型号：GM-J#035045 -Cryorecovery

应用：KOR-Cre knock-in/knock-out mice have the endogenous kappa opioid receptor promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Oprk1-expressing cells/tissues (including neurons of the cortex and striatum, retina, lung, liver, and kidney), and may be useful in studying reward, pain, and nociception.

型号：GM-J#034918 -Cryorecovery

应用：Nur77RFP BAC transgenic mice express turbo red/orange fluorescent protein (tRFP) from the mouse Nr4a1 (nuclear receptor subfamily 4, group A, member 1; Nur77) promoter. These mice are useful in studying thymocyte selection as well as lymphocyte activation, and can be used as a reporter of T cell receptor signaling strength.