型号：GM-J#034746 -Cryorecovery

应用：ROSA26LSL-ER-HRP mice conditionally express endoplasmic reticulum (ER)-targeted horse radish peroxidase (HRP) in a Cre recombinase-dependent manner. Cre recombinase-mediated excision of a loxP-flanked Stop cassette enables directed expression of horse radish peroxidase fused to an endoplasmic reticulum retention signal, useful in multiplexed electron microscopy labeling.

型号：GM-J#034736 -Cryorecovery

应用：vGlut3-P2A-iCreERT2 mice carry a CRISPR/Cas9 generated insertion of a P2A-iCre/ERT2 cassette in exon 12, immediately before the stop codon of the Slc17a8 gene, without disrupting endogenous vesicular glutamate transporter 3 expression. These mice may be used to generate tamoxifen-induced conditional mutations for studying gain-or-loss of function and/or fate mapping related to glutamatergic synaptic vesicle trafficking.

型号：GM-J#034727 -Available

应用：P2ry12-CreER mice express a tamoxifen-inducible Cre driven by the endogenous purinergic receptor P2Y, G-protein coupled 12 (P2ry12) promoter. These mice are a Cre-lox tool, allowing inducible Cre recombination in P2ry12-expressing cells/tissues (primarily microglia), and may be useful in studying neuroinflammation, neurodegenerative disease, and immune response.

型号：GM-J#034694 -Cryorecovery

应用：Ai86(TITL-ArcLight) mice are a Cre/Tet-dependent, voltage-sensitive, fluorescent line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassette by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of the voltage-sensitive fluorescent protein ArcLight. ArcLight exhibits voltage-dependent FRET (Förster resonance energy transfer pairs) upon membrane depolarization, and enables optical recordings at high spatial resolution with intrinsic assignment of recorded signals to targeted cell populations.

型号：GM-J#034665-JAX -Cryorecovery

应用：These microRNA 185 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in embryonic brain and spinal cord. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#034663-JAX -Cryorecovery

应用：These microRNA 150 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#034662-JAX -Cryorecovery

应用：These microRNA cluster 6 (miR-654/miR-376b) conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in embryonic brain and spinal cord. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#034661-JAX -Cryorecovery

应用：These microRNA 688 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in brain. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#034660-JAX -Cryorecovery

应用：These microRNA cluster 28 (miR-296/miR-298) conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#034659-JAX -Cryorecovery

应用：These microRNA cluster 27 (miR-497/miR-195) conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in lung at E18.5. This mutant mouse strain may be useful in studies of microRNA biology.