型号：GM-J#037946 -Available For Registering Interest

应用：RCL-dCreV mice have a loxP-flanked STOP cassette preventing expression of a split, destabilized, light-inducible Cre recombinase. Following exposure to another Cre recombinase source and then subsequent illumination of the appropriate wavelength (~920nm) in the presence of the stabilizing antibiotic trimethoprim (TMP), expression of a functional Cre recombinase enzyme complex is expected. These mice are useful for in vivo targeted optogenomic modifications of single cells or cell populations.

型号：GM-J#037939 -Available For Pre-Order

应用：Ai203 (also called Ai203(TITL-sChroME-Kv2.1-GC7s-WPRE-ICL-nls-mRuby3-IRES2-tTA2-WPRE)) is a Cre recombinase-dependent, Tet-controllable, optogenetic, calcium sensor and fluorescent tool allele created by targeted insertion at the Igs7 locus (TIGRE). Exposure to Cre recombinase results in expression of sChroME*/GCaMP7s, mRuby3, and tTA2 in those cells where cre is expressed.

型号：GM-J#037890 -Available

应用：Rosa26TurboID knock-in mice have the widely-expressed CAG promoter controlling the cre-inducible expression of a V5-tagged biotin ligase sequence, TurboID, with a nuclear export signal. Cre-mediated recombination results in the excision of a STOP sequence, enabling cell-type specific expression of TurboID. These mice provide a tool for in vivo biotinylation of proteins allowing characterization of specific proteomes in multiple tissues.

型号：GM-J#037882 -Available

应用：CRISPR-generated Slc6a2-p2a-Cre knock-in mice express cre recombinase from the mouse solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 (Slc6a2) promoter. This strain has been useful in studies of area postrema excitatory neurons as they relate to nausea-associated behaviors.

型号：GM-J#037843 -Cryorecovery

应用：Exon 3 of the mouse Agpat5 (1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) gene is flanked by lox2272/loxP sites in these Agpat5flox mice. Cre recombinase-mediated excision of the floxed region results in a knock-out allele and expression of a tdTomato reporter useful in studies of agouti-related peptide neurons and their roles in insulin-induced hypoglycemia sensing and glucagon secretion.

型号：GM-J#037804 -Available

应用：Clec9aCreERT2 knock-in mice have a P2A peptide fused to a cre/ERT2 sequence inserted into the C-terminal of the Clec9a gene. This strain is useful for dendritic cell lineage fate mapping and for studying adaptive immune responses to antigens in apoptotic and necrotic cells.

型号：GM-J#037803 -Available

应用：KbStrep knock-in mice have an inverted StrepTagII, flanked by two pairs of inward-facing heterospecific Lox sites, inserted into intron 1 of the H2-K1 gene. Upon cre induction, recombination of the Lox sites results in the inversion of the StrepTagII into the correct transcriptional orientation. These mice may be useful for the selective purification of MHC-I peptide antigens from cell type(s) of interest from intact tissues.

型号：GM-J#037801-JAX -Cryorecovery

应用：The PAC-Tg(SNCAWT);Snca-/-; Gba1L444P/+ mice harbor a Snca knockout allele, a transgene encoding human alpha-synuclein and the L444P mutation in the Gba1 (glucosidase, beta, acid 1) gene associated with the alpha-synucleinopathy, Gaucher disease. This strain serves as an experimental control for STOCK Gba1tm1Rlp Sncatm1Nbm Tg(SNCA*A53T)1Nbm Tg(SNCA*A53T)2Nbm/Mmjax (MMRRC Stock Number 036733).

型号：GM-J#037719 -Available

应用：TIGRE2-jGCaMP8s-IRES-tTA2 knock-in mice co-express the jGCaMP8s genetically encoded calcium indicator (GECI) and a tetracycline controlled tetracycline controlled transactivator (tTA2) in a Cre recombinase-dependent manner from the intergenic Igs7 (TIGRE) locus. The addition of an internal ribosome entry site (IRES) introduced upstream of tTA and the omission of a WPRE enhancer element downstream ameliorate previously reported tTA overexpression toxicity issues. jGCaMP8s is a fast rise, medium decay green fluorescent-based GECI with improved sensitivity and faster kinetics.

型号：GM-J#037718 -Available

应用：TIGRE2-jGCaMP8m-IRES-tTA2-WPRE knock-in mice co-express the jGCaMP8m genetically encoded calcium indicator (GECI) and a tetracycline controlled transactivator (tTA2) in a Cre recombinase-dependent manner from the intergenic Igs7 (TIGRE) locus. An internal ribosome entry site (IRES) introduced upstream of tTA ameliorates previously reported tTA overexpression toxicity issues. jGCaMP8m is noted for its faster decay rate and offers a useful compromise between sensitivity and kinetics.