型号：GM-J#038342 -Cryorecovery

应用：Gas1-creER knock-in mice express an iCreER fusion protein driven by the growth arrest specific 1 (Gas1) endogenous promoter. When these mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in the Gas1-expressing cells of the offspring. These mice may be useful for studying cellular proliferation, apoptosis, embryonic development and tumor suppression in certain cancers.

型号：GM-J#038307 -Available

应用：ROSA26SAT translocation sensor mice conditionally express fluorescent ERK1/2 pathway, ATK pathway, and nuclear reporters from a single Gt(ROSA)26Sor transcript, enabling live-cell in vivo (whole embryo or animal) and ex vivo (cell line) studies of intracellular signaling in response to external stimuli.

型号：GM-J#038306 -Available

应用：ROSA26SAE translocation sensor mice conditionally express fluorescent ERK1/2 pathway and nuclear reporters from a single Gt(ROSA)26Sor transcript, enabling live-cell in vivo (whole embryo or animal) and ex vivo (cell line) studies of intracellular signaling in response to external stimuli.

型号：GM-J#038270 -Cryorecovery

应用：SynaCre CRISPR-derived knock-in mice are designed to have P2A-Cre sequence inserted immediately after the stop codon of the syncytin a gene. The endogenous Syna promoter directs expression of Cre recombinase to placental syncytiotrophoblasts (SCTB1). These mice are useful for studying gene functions in late gestation placentas, as well as for studying pregnancy complications and fetal abnormalities.

型号：GM-J#038257 -Cryorecovery

应用：KRT13-CreER knock-in mice express tamoxifen-inducible cre/ERT2 recombinase from the mouse keratin 13 (Krt13) promoter in hillock cells of the tracheal epithelium. This strain has been useful in hillock cell lineage tracing studies with implications for injury repair, squamous metaplasia, and lung cancer.

型号：GM-J#038210 -Available For Pre-Order

应用：Prkn-floxed mice possess loxP sites flanking exon 7 of the parkin RBR E3 ubiquitin protein ligase (Prkn) gene. These mice may be useful in generating conditional mutations to study the role of PRKN in multiple diseases caused by mitochondrial dysfunction, such early-onset Parkinson's disease.

型号：GM-J#038201 -Available For Pre-Order

应用：RARCre transgenic mice express Cre recombinase under the control of the murine retinoic acid receptor, beta (Rarb) promoter. They may be useful when studying cellular growth and differentiation.

型号：GM-J#038200 -Cryorecovery

应用：SynbCre CRISPR-derived knock-in mice are designed to have P2A-Cre sequence inserted immediately after the stop codon of the syncytin b gene. The endogenous Synb promoter directs expression of Cre recombinase to the placental syncytiotrophoblast 2 (SCTB2) layer of the placenta. These mice are useful for studying gene functions in late gestation placentas, as well as for studying pregnancy complications and fetal abnormalities.

型号：GM-J#038197 -Available

应用：Nmur1iCre-eGFP mice express iCre and eGFP driven by the neuromedin U receptor 1 (Nmur1) promoter. When these mice are bred with mice containing a loxP-flanked sequence of interest, Cre-mediated recombination will result in deletion of the floxed sequences in Nmur1-expressing cells of the offspring (Tsou et al., Nature 2022). These mice also express eGFP in Nmur1-expressing cells. These Nmur1iCre-eGFP mice may be useful for studying function and lineage mapping of Nmur1-positive cells.

型号：GM-J#038175 -Available For Registering Interest

应用：These hCD68-CreERT2 knock-in mice express an inducible cre/ERT2 fusion gene under the control of the human CD68 promoter. Following administration of tamoxifen, mice express Cre recombinase in CD11b+ F4/80+ macrophages, peritoneal, liver and spleen macrophages, and blood Ly6Clow monoctyes. These mice can be used to target tissue resident macrophages without targeting other myeloid cells.