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  • 型号:GM-J#038175 -Available For Registering Interest

    应用:These hCD68-CreERT2 knock-in mice express an inducible cre/ERT2 fusion gene under the control of the human CD68 promoter. Following administration of tamoxifen, mice express Cre recombinase in CD11b+ F4/80+ macrophages, peritoneal, liver and spleen macrophages, and blood Ly6Clow monoctyes. These mice can be used to target tissue resident macrophages without targeting other myeloid cells.

    2024-11-09 点击次数:0

    型号:GM-J#038164 -Available For Pre-Order

    应用:ROSA26-tdRFP knock-in mice allow cre-inducible expression of a robust tandem dimer RFP (tdRFP) fluorescent reporter from the ubiquitously expressed Gt(ROSA)26Sor locus. This strain may be useful as a tool that is compatible with GFP- or YFP-expressing mice for in vivo lineage tracing and fate-mapping studies.

    2024-11-09 点击次数:0

    型号:GM-J#038161 -Cryorecovery

    应用:pTαiCre knock-in/knock-out mice carry a codon optimized Cre recombinase (icre) inserted into the Ptrca (pre T cell antigen receptor alpha) locus. Homozygous KO mice have decreased numbers of thymocytes. This strain may be useful for lineage tracing experiments in studies of T cell lymphopoiesis.

    2024-11-09 点击次数:0

    型号:GM-J#038152 -Available

    应用:IgkTag (K-tag) knock-in mice have a loxP-flanked FLAG-tag, followed by stop codons and an SV40 polyadenylation sequence, and Strep-II tag inserted into the C-terminus of the immunoglobulin kappa chain complex (Igk) gene. Prior to Cre exposure, mice express FLAG-tagged B cell receptors. Upon Cre exposure, recombination of the loxP sites results in the removal of the FLAG-tag and expression of the Strep-II tag in Cre-expressing tissues. These mice allow for molecular fate-mapping of serum antibodies and can specifically be used to ascribe the cellular and temporal origin of serum antibodies to B cell reactions of interest.

    2024-11-09 点击次数:0

    型号:GM-J#038129 -Cryorecovery

    应用:Ascl3P2A-GCE knock-in mice express an eGFP/iCreERT2 fusion protein in achaete-scute family bHLH transcription factor 3 (Ascl3)-expressing cells while retaining endogenous Ascl3 activity. When these mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre recombinase activity is detected in the Ascl3-expressing cells of the offspring. Of note, the donating investigator has indicated that eGFP expression is not detectable either by direct fluorescence or immunohistochemistry.

    2024-11-09 点击次数:0

    型号:GM-J#038113 -Cryorecovery

    应用:Nps-2A-Cre CRISPR-derived knock-in mice are designed to have 2A-Cre sequence inserted downstream of the coding region of the neuropeptide S gene. The endogenous Nps promoter directs expression of Cre recombinase to neurons in the amygdala and in the brain stem near the parabrachial nucleus (PB) involved in wakefulness and anxiety-related behaviors. These mice are useful for studying the connectivity and function of NPS neurons.

    2024-11-09 点击次数:0

    型号:GM-J#038073 -Cryorecovery

    应用:PSD95-lox-Stop-lox-TimeSTAMP2 mice have a loxP-flanked STOP codon and the TimeSTAMP cassette replacing the endogenous STOP codon of the Dlg4 gene. The TimeSTAMP (Time-Specific Tagging for the Age Measurement of Proteins) cassette contains N- and C-terminal Venus fragments separated by a cis-cleaving hepatitis C virus (HCV) NS3 protease, and a 2xHA-tag, expression of which is blocked by the presence of a loxP-flanked STOP cassette. After Cre induction, deletion of the STOP cassette allows the expression of PSD95-TimeSTAMP after administration of the NS3 inhibitor drug asunaprevir (ASV). This strain is useful for visualizing newly synthesized PSD95 where preservation of normal neuronal function is required.

    2024-11-09 点击次数:0

    型号:GM-J#038053 -Available

    应用:Oprm1-cre knock-in mice express an eGFP/Cre fusion protein in opioid receptor, mu 1-expressing cells while retaining endogenous Oprm1 activity. These mice may be used for studying the expression and activity pattern of Oprm1-expressing cells.

    2024-11-09 点击次数:0

    型号:GM-J#038021 -Available For Pre-Order

    应用:MI2 mice harbor an α-Syn null allele and a truncated (1-120) human α-synuclein transgene driven by the rat Th promoter. These mice may be useful for studying the pathogenic role of α-synuclein in synucleinopathies, such as Parkinson's Disease.

    2024-11-09 点击次数:0

    型号:GM-J#037964 -Cryorecovery

    应用:Vip-IRES-Cre mice have Cre recombinase expression directed to Vip-expressing cells by the endogenous promoter/enhancer elements of the vasoactive intestinal polypeptide locus. Cre activity is detected in the neocortex, hippocampus, olfactory bulb, suprachiasmatic nuclei, and other discrete midbrain and brainstem regions. These mice may be useful to study neural GABAergic circuits throughout the mammalian brain.

    2024-11-09 点击次数:0
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