型号：GM-J#004783 -Cryorecovery

应用：These Sox2Cre transgenic mice express Cre recombinase under the control of the mouse Sox2 (SRY-box containing gene 2) promoter, and may be useful for generating epiblast-derived specific conditional mutations.

型号：GM-J#004782 -Cryorecovery

应用：A congenic version of this strain is available as Stock No. 018964.

型号：GM-J#004781 -Available Now

应用：The LysMcre knock-in/knock-out allele has a nuclear-localized Cre recombinase inserted into the first coding ATG of the lysozyme 2 gene (Lyz2); both abolishing endogenous Lyz2 gene function and placing NLS-Cre expression under the control of the endogenous Lyz2 promoter/enhancer elements. These LysMcre mice may be useful for Cre-lox studies of the myeloid cell lineage (monocytes, mature macrophages and granulocytes) and the innate immune response.

型号：GM-J#004746 -Cryorecovery

应用：A C57BL/6 congenic version of this strain is available as Stock No. 017491.

型号：GM-J#004744 -Cryorecovery

应用：This Esr1 mutant strain is a functional knock out of ERα. Female mice homozygous for this mutation are infertile, exhibit cystic ovaries that lack corpora lutea and hypoplastic uteri that are unresponsive to estrogen. Homozygous males show reduced testis weight associated with diminished sperm count. These mice may be suitable for use in studies related to estrogen signaling, estrous cycle, obesity, metabolic syndrome and hormonal regulation of a variety of organ systems.

型号：GM-J#004692 -Cryorecovery

应用：These HoxB7/Cre mice express a transgene containing Cre recombinase and show Low levels of expression in the dorsal root ganglia and the spinal cord.

型号：GM-J#004682 -Available Now

应用：When these CAGGCre-ERTM mice are bred with mice carrying a floxed target gene, tamoxifen-inducible Cre-mediated recombination results in deletion of the floxed sequences in widespread cells or tissues of the offspring, including developing embryos and cultured cells derived from transgenic mice.

型号：GM-J#004608 -Cryorecovery

应用：These mice carry a spontaneous mutation at the Htra2 locus characterized by a basal ganglia disorder resulting in muscle atrophy, hunched posture, increased imbalance, chorea, dystonia, and progressive akinesis.

型号：GM-J#004600 -Cryorecovery

应用：Homozygotes for this transgene are not viable. Hemizygotes express Cre recombinase under the control of the human glial fibrillary acidic protein promoter (GFAP). When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target, and recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. This mutant mouse strain represents an effective tool for generating central nervous system specific-targeted mutants.

型号：GM-J#004586 -Available

应用：These Vil1-cre mice express Cre recombinase in villus and crypt epithelial cells of the small and large intestines and may be useful in studies of intestinal organogenesis. In contrast to Villin-cre transgenic mice from founder line 1000 (Stock No. 021504) that are reported be absent of Cre recombinase activity in gonads, these Villin-cre transgenic mice from founder line 997 are reported to have a very low level (<1%) of cells with Cre recombinase activity in the testes.