型号：GM-J#005249 -Cryorecovery

应用：These transgenic mice express a RU 486-inducible cre recombinase driven by the mouse keratin complex 1, acidic, gene 15 promoter. When induced, cre activity is observed in epithelial stem cells in the bulge region of the hair follicle. These mice may be useful to study epithelial and hair follicle stem cells lineage.

型号：GM-J#005130 -Available

应用：When these mice are used in conjunction with a Cre recombinase-expressing strain, successful Cre-mediated excision results in the constitutive expression of the Smo/EYFP fusion gene (monitored by using EYFP-specific fluorescence protocols) and unrestrained Hedgehog signaling in Cre-expressing tissues. As examples, this strain may be useful in studies of tumorigenic potential in the hedgehog pathway, progenitor cell involvement in the development of medulloblastomas, craniofacial development, thalamic development, and of oligodendrocyte maturation and CNS myelination when used in combination with specific cre-expressing strains.

型号：GM-J#005125 -Available

应用：This strain serves as a Cre reporter strain. When used in conjunction with a Cre recombinase-expressing strain, successful Cre-mediated excision is indicated by luciferase expression in Cre-expressing tissues.

型号：GM-J#005107 -Available

应用：These transgenic mice have a tamoxifen inducible Cre-mediated recombination system driven by the human keratin 14 (KRT14) promoter, which is active in dividing cells of epidermis and some other stratified squamous epithelia. When crossed with a strain containing a loxP site flanked sequence of interest, the offspring can be used to generate tamoxifen-induced, Cre-mediated targeted keratinocyte-specific deletions. This strain may be useful for studying somatic mutations of the skin, including squamous and basal cell carcinomas.

型号：GM-J#005105 -Cryorecovery

应用：These Chx10 BAC mice express a transgene containing EGFP and human placental alkaline phosphatase with reporter activity being seen in a subset of Müller glial cells.

型号：GM-J#005069 -Cryorecovery

应用：The FABP4-Cre transgene has a mouse Fabp4 promoter directing expression of Cre recombinase. These FABP4-Cre transgenic mice are a Cre-lox tool useful for deletion of floxed sequences in brown and white adipose tissue.

型号：GM-J#004987 -Cryorecovery

应用：These NOD.RIPCre6 mice express cre recombinase in pancreatic beta cells.

型号：GM-J#004986 -Cryorecovery

应用：These NOD.RIPCre3 mice express cre recombinase in pancreatic beta cells.

型号：GM-J#004936 -Available

应用：Homozygotes exhibit disorganized ultrastructural wound matrix remodeling and defective macrophage infiltration and accumulation at sites of injury and infection. Mutant macrophage response to mycobacteria infection and pulmonary granulomatous response and inflammation are impaired. This mutant mouse strain may be useful in studies of carcinogenesis, tissue remodeling, wound repair, fibrosis and granulomatous diseases.

型号：GM-J#004847 -Cryorecovery

应用：These R26CreER mutant mice have a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions.