型号：GM-J#003771 -Available

应用：This strain is commonly known as nestin-Cre. Nestin promotor driven Cre recombinase is expressed in the central and peripheral nervous system, including neuronal and glial cell precursors. There are reports of Cre recombinase activity in a few isolated kidney and heart cells. Hemizygous nestin-cre mice exhibit mild hypopituitarism, growth retardation, impaired fear response, and a metabolic phenotype. Mice also show a strong impairment in the acquisition of both contextual- and cued-fear conditioning.

型号：GM-J#003755 -Cryorecovery

应用：This knock-in strain expresses Cre recombinase under the control of the endogenous Meox2 promoter with Cre recombinase active in early embryos. These mice can be utilized as a deleter strain for floxed genes and provide an alternative to tetraploid embryo analysis.

型号：GM-J#003734 -Cryorecovery

应用：The granzyme-B-Cre transgene is designed to have the human GZMB (granzyme B) promoter directing Cre recombinase expression to activated T cells.

型号：GM-J#003724 -Available

应用：EIIa-cre mice carry a cre transgene under the control of the adenovirus EIIa promoter that targets expression of Cre recombinase to the early mouse embryo, and are useful for germ line deletion of loxP-flanked genes.

型号：GM-J#003692 -Cryorecovery

应用：Homozygous null mice suffer from a reduction in total striatal dopamine and exhibit an attenuated locomotor response when given amphetamine. Observed phenotype suggests that Snca is an activity-dependent negative regulator of dopamine neurotransmission. These mice may be useful in studies relating to Parkinson's disease.

型号：GM-J#003651 -Available

应用：cre expression in these mice is controlled by regulatory sequences from the mouse zona pellucida 3 (Zp3) promoter, which normally directs expression exclusively in the growing oocyte prior to the completion of the first meiotic division. This strain would be useful for deleting a floxed sequence specifically in the female germ line.

型号：GM-J#003574 -Available Now

应用：Alb-cre mice are useful for deletion of loxP-flanked genes in the liver. Please note: this strain also is available on the 129 background (Stock No. 035593).

型号：GM-J#003573 -Available

应用：The RIP-Cre transgene has a 668 bp fragment of the rat insulin II promoter, nuclear-localized Cre recombinase, and a 2.1 kbp fragment from the human growth hormone gene. These RIP-Cre transgenic mice are a Cre-lox tool useful for deletion of floxed sequences in pancreatic beta cells.

型号：GM-J#003556 -Available

应用：The Cre recombinase is under the control of the Mx1 promoter, which can be induced to high levels of transcription by administration of interferon alpha, interferon beta, or synthetic double-stranded RNA (such as poly I:C); enabling the "knockout" at any time during development in progeny of a floxed mutant mated to this transgenic.

型号：GM-J#003554 -Cryorecovery

应用：Col2a1-Cre (Col2-Cre) transgenic mice express Cre recombinase in a chondrocyte-specific pattern under the control of a Col2a1 promoter, which is active in differentiating chondrocytes, notochord and submandibular glands.