型号：GM-J#015833 -Cryorecovery

应用：This floxed Rims2 (regulating synaptic membrane exocytosis 2) mutation strain enables cre-mediated excision of the α, β, and γ isoforms of the gene and may be useful in studies of synaptic neurotransmission.

型号：GM-J#014647 -Available

应用：These Pdx-Cre transgenic mice express Cre recombinase under the control of the mouse Pdx1 promoter and may be useful for generating pancreas-specific conditional mutations.

型号：GM-J#014643 -Cryorecovery

应用：These Chm:Cre transgenic mice express cre under the control of the baboon CMA1, chymase 1, mast cell, promoter and may be useful for generating conditional mutations for studying gain/loss of function or fate mapping in resident mast cell lineages of the colon and lung.

型号：GM-J#014600 -Cryorecovery

应用：These transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse I12b enhancer element of Dlx1/2, and may be useful for generating temporal conditional mutations for studying gain or loss of function and/or fate mapping in Dlx1/2-expressing forebrain tissues, including interneurons of the olfactory bulb and neocortex.

型号：GM-J#014554 -Available

应用：The SERT-cre (SERTcre) "knock-in" allele has a nuclear-localized Cre recombinase inserted just upstream of the first coding ATG of the serotonin transporter gene (Slc6a4; SERT or 5-HTT). This was designed to both abolish gene function and place Cre recombinase expression under the control of the SERT promoter/enhancer elements.

型号：GM-J#014552 -Cryorecovery

应用：The Nkx2.1-CreER (or Nkx2.1-CreERT2) knock-in/knock-out allele expresses a tamoxifen-inducible Cre recombinase from the endogenous promoter/enhancer elements of the NK2 homeobox 1 (Nkx2-1) gene. When induced, CreERT2 expression recapitulates endogenous Nkx2-1 expression, mainly in the medial and caudal ganglionic eminences of the basal ganglia and the preoptic area. These mice may be useful in studying the role of medial ganglionic eminences progenitor cells in GABAergic neuron development, as well as lung, thyroid, and pituitary development.

型号：GM-J#014551 -Cryorecovery

应用：The Dlx1-CreERT2 knock-in allele was designed to both abolish distal-less homeobox 1 (Dlx1) gene function and direct CreERT2 fusion protein expression to Dlx1 positive neurons (including cortical GABAergic neurons, striatal neurons, and olfactory neurons) by the endogenous Dlx1 promoter/enhancer elements. Cre-ERT2 fusion gene activity is inducible by tamoxifen administration.

型号：GM-J#014541 -Cryorecovery

应用：The nNOS-CreER-KI knock-in allele was designed to both abolish neuronal nitric oxide synthase 1 (Nos1) gene function and direct CreERT2 fusion protein expression to nNOS positive GABAergic neurons by the endogenous Nos1 promoter/enhancer elements. Cre-ERT2 fusion gene activity is inducible by tamoxifen administration.

型号：GM-J#014539 -Available

应用：These Ai39 mice conditionally express an improved Halorhodopsin/EYFP fusion protein from the endogenous Gt(ROSA)26Sor locus. Following Cre-mediated removal of the STOP cassette, EYFP expression is observed in the cre-expressing cells. Subsequent illumination of these cells with yellow-to-red light leads to reversible photoinhibition of action potential firing/neural activity in these cells. These Ai39 mice are useful for optogenetic studies to express an inhibitory opsin that effectively silences the activity of cortical neurons.

型号：GM-J#014538 -Cryorecovery

应用：A C57BL/6J congenic version of this Ai38 strain will remain available as Stock No. 029043).