型号：GM-J#013233 -Cryorecovery

应用：These CD11c-Cre-GFP transgenic mice may be useful in immunological studies, specifically Type 1 Diabetes, utilizing Cre-lox technology or fluorescent protein expression in dendritic cells.

型号：GM-J#013148 -Available

应用：Cre recombinase expression in hemizygous Pdgfra-cre mice is directed to Muller glial cells by endogenous promoter/enhancer elements of the Pdgfra gene. These mice may be useful for generating conditional mutations for studying retinal degeneration, retinitis pigmentosa, macular degeneration, and the role of Muller glial cells in progressive neuronal cell death.

型号：GM-J#013110 -Cryorecovery

应用：Mutant mice exhibit hind limb atrophy and a progressive decrease in body weight leading to paralysis and premature death.

型号：GM-J#013050 -Cryorecovery

应用：These knock-in mice contain a mutation designed to replace gene function of the endogenous mouse Pink1 gene with the loss-of-function mutation, G309D, and a loxP-flanked neomycin resistance cassette (neo). These mice show increasing mitochondrial dysfunction resulting in impaired neural activity similar to PD, in absence of overt neuronal death.

型号：GM-J#013048 -Cryorecovery

应用：The Etv1-CreERT2 knock-in allele was designed to both abolish ets variant gene 1 (Etv1) gene function and direct CreERT2 fusion protein expression to ER81 positive neurons (including Layer5 pyramidal neurons) by the endogenous Etv1 promoter/enhancer elements. Cre-ERT2 fusion gene activity is inducible by tamoxifen administration.

型号：GM-J#013044 -Available Now

应用：Sst-IRES-Cre knock-in mice express Cre recombinase in somatostatin-expressing neurons. These mice may be useful in studying dendritic inhibitory interneurons such as Martinotti cells and Oriens-Lacunosum-Moleculare cells.

型号：GM-J#012929 -Cryorecovery

应用：The Dhh-cre transgene harbors a nuclear-localized Cre recombinase gene under control of the mouse desert hedgehog (Dhh) promoter/regulatory regions. These transgenic mice may be useful in generating cre-inducible mutations in Sertoli cell precursors (testes development/male germline), endothelial cells, and Schwann cells of the peripheral nervous system.

型号：GM-J#012906 -Cryorecovery

应用：The nestin-CreER transgene contains the rat nestin enhancer/hsp68 minimal promoter directing expression of a tamoxifen-inducible Cre recombinase (Cre-ERT1). When these nestin-CreER transgenic mice are bred with mice containing a loxP-flanked sequence, tamoxifen-inducible Cre-mediated recombination is expected to result in deletion of the floxed sequences in the Cre recombinase-expressing tissues of the offspring. These mice may be useful for studying embryonic and adult neurogenesis.

型号：GM-J#012887 -Not Available At Jax

应用：In 2014, The Jackson Laboratory Stock No. 012887 was confirmed to have the same expression pattern as GFAP-Cre line 73.12 (Stock No. 012886). Therefore, Stock No. 012887 was discontinued. To replace it, The Jackson Laboratory is offering the correctly-expressing GFAP-Cre line 77.6 mice from Dr. Michael Sofroniew to establish a new GFAP-Cre line 77.6 colony as Stock No. 024098.

型号：GM-J#012886 -Available

应用：This strain is undergoing recovery from cryopreserved stocks.