型号：GM-J#016575 -Cryorecovery

应用：G2019S-LRRK2 transgenic mice have a minimal cytomegalovirus (CMV) enhancer and human platelet derived growth factor, B polypeptide (PDGFB) promoter/enhancer elements driving expression of a mutated full length human leucine-rich repeat kinase 2 (LRRK2*G2019S) cDNA. These mice may be useful for studying Parkinson's Disease pathogenesis and neurodegeneration elicited by the dominant toxic effects of mutant LRRK2*G2019S expression.

型号：GM-J#016566 -Cryorecovery

应用：HCN1 knock-out mice lack the p region and S6 transmembrane (pore-S6) domain of the hyperpolarization-activated, cyclic nucleotide-gated K+ 1 (Hcn1) gene. This mutant mouse strain may be useful in studies of learning, memory, neurophysiology, and Parkinson's Disease.

型号：GM-J#016539 -Cryorecovery

应用：These Cripto2loxP mice possess a loxP-sites flanking exons 3-5 of the cripto, EGF-CFC family member (Cripto formerly Tdgf1) gene. This strain may be useful for studying embryonic development and tumor growth.

型号：GM-J#016261 -Available

应用：Nestin-Cre/ERT2 transgenic mice express tamoxifen-inducible Cre recombinase in adult and developing mouse brain, including neuronal and glial cell precursors.

型号：GM-J#016241 -Cryorecovery

应用：This Col1a1-CreERT2 mutant mouse strain carries a transgene with tamoxifen inducible Cre recombinase and may be useful for generating osteoblast and odontoblast specific targeted mutants for studies of bone physiology and homeostasis.

型号：GM-J#016236 -Cryorecovery

应用：TopCreERT2 transgenic mice express a CreERT2 fusion protein under the control of three copies of a T cell specific transcription factor/lymphoid enhancer-binding factor 1 (TCF/Lef1) response element and a c-fos minimal promoter. This strain may useful for studying the Wnt signaling pathway.

型号：GM-J#016225 -Available

应用：These mice express a tamoxifen-inducible form of cre recombinase from the Scgb1a1 locus (secretoglobin). This strain may useful for inducing cre recombinase activity in bronchiolar non-ciliated Clara cells.

型号：GM-J#016223 -Available

应用：Phox2b-Cre BAC transgenic mice have Cre recombinase expression directed primarily to the hindbrain by the Phox2b promoter/enhancer regions, and may be used to generate conditional mutations for studying neuronal cell types expressing or depending on the Phox2b transcription factor. Specifically, these mice may be useful for studying human respiratory disease, central chemoreceptive neurons in the retrotrapezoid nucleus, respiratory rhythmogenesis, and autonomic nervous system dysregulation (such as congenital central hypoventilation syndrome (CCHS) or Ondine-Hirschsprung disease).

型号：GM-J#016222 -Cryorecovery

应用：This Id2-CreERT2 knock-in allele was designed to both abolish Id2 gene function and direct CreERT2 fusion protein expression from the endogenous Id2 promoter/enhancer elements. Cre-ERT2 fusion gene activity is inducible by tamoxifen administration.

型号：GM-J#016210 -Cryorecovery

应用：LRRK2 KO2 mice have with exons 29-30 of the Lrrk2 gene deleted. These mice may be useful in studying the cellular function of LRRK2 during aging in the maintenance of protein homeostasis and, specifically, α-synuclein through the regulation of protein degradation pathways.