型号：GM-J#013725 -Cryorecovery

应用：These LRRK2-Wt mice express a wild-type human leucine-rich repeat kinase 2 (LRRK2) gene directed by the human LRRK2 promoter/enhancer regions on the BAC transgene. These mice may be useful for studying normal function of LRRK2 function and the pathogenesis of Parkinson's disease.

型号：GM-J#013594 -Cryorecovery

应用：This knockin mutation replaces the coding sequence of the (Atoh1) gene with a modified Cre-recombinase-progesterone receptor fusion protein (Cre-PR). The fusion gene activity is inducible by administration of RU486.

型号：GM-J#013590 -Available

应用：Due to tumor onset and progression, shipment of HEMI HET HOM males and females of this strain is restricted to four to eight weeks of age.

型号：GM-J#013587 -Cryorecovery

应用：These 5172 3-state Cre-sensitive (5172 3SCS) mice contain a construct designed to insert (from 5' to 3') a floxed-STOP cassette, tdTomato open reading frame (ORF), and a floxed-internal ribosome entry site (IRES) fused to an enhanced green fluorescent protein (GFP) ORF. The IRES-eGFP element was flanked by 5172 mutant loxP sites (which recombine at 30% the efficiency of wildtype loxP sites). This vector was inserted into the Gt(ROSA)26Sor locus allowing for widespread expression. These 5172 3SCS mice are of general use for detecting cells that have expressed the Cre recombinase, for Cre recombinase-based lineage marking experiments, and in particular for applications in which it is useful to discriminate cells that differ in how much Cre recombinase they have expressed.

型号：GM-J#013586 -Cryorecovery

应用：These 3373 S-state Cre-sensitive (3373 3SCS) mice contain a construct designed to insert (from 5' to 3') a splice acceptor (SA) sequence, a loxP site, a puromycin selection cassette, an SV40 polyadenylation (polyA) cassette, another loxP site, tdTomato open reading frame (ORF), an internal ribosome entry site (IRES) fused to an enhanced green fluorescent protein (GFP) flanked by 3373 loxP sites, followed by a second polyA cassette. The loxP sites flanking the 5' polyA cassette are in opposite orientation to the loxP sites flanking the 3' IRES-GFP cassette, and all are modified allowing for only 10% of the recombination efficiency of native loxP sites. This vector was inserted into the Gt(ROSA)26Sor locus allowing for widespread expression. These 3373 3SCS mice are of general use for detecting cells that have expressed the Cre recombinase, for Cre recombinase-based lineage marking experiments, and in particular for applications in which it is useful to discriminate cells that differ in how much Cre recombinase they have expressed.

型号：GM-J#013583 -Cryorecovery

应用：These hemizygous transgenic mice carry a human leucine-rich repeat kinase 2 gene, LRRK2, regulated by a tetracycline operator (tetO). When mated to a mutant strain expressing tetracycline-controlled transactivator protein (tTA), expression of LRRK2 protein may be regulated with the tetracycline analog doxycycline (dox) in the double mutant offspring. These mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration.

型号：GM-J#013536 -Cryorecovery

应用：In this strain, codon 103 in exon 3 of the endogenous mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1 or Jip1) gene is mutated from a Threonine (ACT) to an Alanine (GCC). These mice may be useful for studying MAP kinase signaling pathways and activation of JNK in response to metabolic stress.

型号：GM-J#013535 -Cryorecovery

应用：In this knockout strain, a neomycin resistance cassette replaces exon 3 of the endogenous mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1 or Jip1) gene. These mice may be useful for studying MAP kinase signaling pathways and stress-induced activation of JNK.

型号：GM-J#013251 -Cryorecovery

应用：These EIIa-Cre transgenic mice express Cre recombinase under the control of the adenovirus EIIa promoter. When crossed with a strain containing loxP site-flanked sequences, Cre-mediated recombination occurs in a wide range of tissues, including germ cells that transmit the genetic alteration to progeny.

型号：GM-J#013234 -Cryorecovery

应用：CD4-Cre transgenic mice contain CD4 enhancer, promoter and silencer sequences driving the expression of a Cre recombinase gene. These mice may be useful for generating conditional mutations in CD4-expressing tissues.