型号：GM-J#016209 -Cryorecovery

应用：LRRK2 KO1 mice have the promoter and exon 1 of the Lrrk2 gene deleted. These mice may be useful in studying the cellular function of LRRK2 during aging in the maintenance of protein homeostasis.

型号：GM-J#016207 -Cryorecovery

应用：Mecp2*A140V mice contain the amino acid mutation A140V in exon 4 of the endogenous methyl CpG binding protein 2 gene, and loxP sites flanking exons 3-4. These mice may be useful for studying impaired neurodevelopmental maturation associated with human RTT.

型号：GM-J#016198 -Cryorecovery

应用：The calcium/calmodulin-dependent protein kinase II alpha (sometimes referred to as CaMKII-tTA) transgene in these mice is a "Tet-Off" system that allows inducible control over expression of genes in forebrain neurons, and may be useful in studying brain disorders such as Alzheimer's disease, Parkinson's disease, or other neurodegenerative diseases.

型号：GM-J#016123 -Available

应用：This knock-out mutation strain lacks exons 1 through 4 of the Snca (synuclein, alpha) gene.

型号：GM-J#016122 -Not Available At Jax

应用：Stock No. 016122 has been discontinued. Researchers can assemble this double mutant strain by breeding Stock No. 016120 mice and Stock No. 016121 mice together.

型号：GM-J#016121 -Cryorecovery

应用：These knock-out mice lack exons 39-40 of the leucine-rich repeat kinase 2 (Lrrk2) gene and may be useful for studying the role of Lrrk2 in the progression of Parkinson's Disease.

型号：GM-J#016120 -Cryorecovery

应用：These Lrrk1 knock-out mice may be useful for studying the role of Lrrk1 in the progression of Parkinson's Disease.

型号：GM-J#016097 -Cryorecovery

应用：This CAC5 transgenic mouse strain expresses Cre recombinase under the control of the mouse Car1 promoter and may be useful in generating large intestine specific-targeted mutants for colon disease research. It has been determined that the transgene inserted on chr 8 (details below); there are no genes annotated in the region of the insertion.

型号：GM-J#015855 -Available For Registering Interest

应用：This strain is currently unavailable due to replenishing of cryopreserved stocks. Interested customers who register interest will be contacted when the strain is again available.

型号：GM-J#015854 -Cryorecovery

应用：These Fox L2-GCE mutant knock in mice utilize a tamoxifen inducible Cre-mediated recombination system and may be useful in studies of genitourinary system development.