型号：GM-J#030759 -Cryorecovery

应用：Mc4r-2a-Cre knock-in mice may be useful for studying appetite control and obesity.

型号：GM-J#030757 -Available

应用：NDNF-ires-Cre knock-in mice (also called NDNF-Cre) are designed to have the endogenous neuron-derived neurotrophic factor promoter/enhancer driving Cre expression, as well as to retain endogenous Ndnf expression. These mice may be used to generate conditional mutations for studying gain-or-loss of function, fate mapping and/or circuit dissection of NDNF+ cell populations.

型号：GM-J#030744 -Available

应用：The constitutively-expressed R26-CAG-ASC-citrine allele has the Gt(ROSA)26Sor locus and CAG promoter directing widespread expression of a fluorescent adaptor fusion protein (ASC-citrine) that retains the function of endogenous ASC - forming assembled inflammasome complexes (specks) upon exposure to inflammasome activator(s) both in vitro and in vivo. These R26-CAG-ASC-citrine mice are a fluorescent reporter of inflammasome complex activation.

型号：GM-J#030743 -Cryorecovery

应用：The R26-CAG-LSL-ASC-citrine floxed allele has a CAG promoter and loxP-flanked STOP cassette upstream of the ASC-citrine fusion protein, all inserted into the Gt(ROSA)26Sor locus. Following removal of the floxed-STOP cassette, they express a fluorescent adaptor fusion protein (ASC-citrine) that retains the function of endogenous ASC - forming assembled inflammasome complexes (specks) upon exposure to inflammasome activator(s) both in vitro and in vivo. These R26-CAG-LSL-ASC-citrine mice are a Cre recombinase-dependent fluorescent reporter of inflammasome complex activation.

型号：GM-J#030681 -Cryorecovery

应用：GcgCreER2 mice express tamoxifen-inducible Cre recombinase under the direction of the glucagon promoter and in pancreatic alpha cells.

型号：GM-J#030676 -Cryorecovery

应用：TgCreERT2 mice express creERT2 directed by thyroglobulin (Tg) promoter on a PAC transgene. These mice may be useful for thyroid specific gene deletion.

型号：GM-J#030663 -Cryorecovery

应用：GcgiCre knock-in mice express a codon improved Cre recombinase gene in pancreatic alpha cells under the direction of the glucagon promoter.

型号：GM-J#030656 -Cryorecovery

应用：The Atp4b-Cre transgene has the parietal cell-specific promoter elements directing expression of Cre recombinase. They may be useful in Cre-lox studies of the stomach - such as gastric cancer, digestive disorders, gastric oxidative stress, endocrine-mediated gastric repair, etc.

型号：GM-J#030644 -Cryorecovery

应用：This transgenic cre strain (also called FSP1cre) may be useful for generating fibroblast specific-targeted mutants.

型号：GM-J#030604 -Cryorecovery

应用：This CRISPR/Cas9 generated mutant of the Lrrtm1 gene carries a cre/ERT2 knock-in mutation in the 3' UTR near the stop codon.