型号：GM-J#031386 -Cryorecovery

应用：Esr1-iCre knock-in/knock-out mice express codon optimized Cre recombinase from the endogenous Esr1 locus. Cre recombinase expression mimics endogenous Esr1 gene expression.

型号：GM-J#031365 -Cryorecovery

应用：IL-9 reporter (9er) knock-in/knock-out mice express humanized cre recombinase (hCre; iCre) and EYFP fluorescent from the mouse Il9 promoter. Endogenous Il9 expression is blocked. This strain is useful in labeling and manipulating cells expressing Il9, for example group 2 innate lymphoid cells (ILC2) cells associated with chitin-induced inflammatory responses in the lung.

型号：GM-J#031364 -Cryorecovery

应用：ChiaRed mice, useful in studies of chitin-induced inflammation and age-related lung fibrosis, express tdTomato and humanized cre recombinase (hCre; iCre) from the mouse Chia1 (AMCase) gene. Endogenous expression of Chia1 is knocked out in this allele.

型号：GM-J#031358 -Cryorecovery

应用：Tg(Tff1-cre/ERT2,Tff2-rtTA,Tff3-luc) transgenic mice express tamoxifen-inducible Cre recombinase, doxycline-mediated rtTA and luciferase in gastric epithelium.

型号：GM-J#031334 -Cryorecovery

应用：Ai134(TITL-ChR2H134R-EYFP)-D mice (also called Ai134D or Ai134(TITL-ChR2-YFP)-D) are a Cre/Tet-dependent, optogenetic line - created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Following Cre-mediated removal of the STOP cassette, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of an improved channelrhodopsin2/EYFP fusion protein (ChR2(H134R)-EYFP). Subsequent illumination of ChR2(H134R)-expressing (EYFP fluorescent) cells with blue light leads to reversible photostimulation of action potential firing/neural activity in these cells.

型号：GM-J#031333 -Cryorecovery

应用：Npr3-IRES2-Cre-D knock-in mice are designed to have Cre recombinase expression/activity directed by the endogenous natriuretic peptide receptor 3 promoter/enhancer sequences. In the brain, Cre expression is observed to be enriched in cortical layer 5 and in restricted cell populations within the hippocampal formation. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in NPR3-expressing cells.

型号：GM-J#031332 -Cryorecovery

应用：Vipr2-IRES2-Cre-D knock-in mice are designed to have Cre recombinase expression/activity directed by the endogenous vasoactive intestinal peptide receptor 2 promoter/enhancer sequences. In the brain, it is observed in arcuate hypothalamic nucleus, dorsal lateral geniculate nucleus, ventral nucleus of the thalamus and bed nuclei of the stria terminalis, with scattered expression in superior colliculus and throughout the cortex. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in VIPR2-expressing cells.

型号：GM-J#031330 -Cryorecovery

应用：These 6ax:pVBI347-L2 compound mutant mice carry a targeted knock-out allele of the endogenous mouse Gdf6 gene in addition to a 3' GDF6 enhancer transgene derived from chimpanzee (lacking in humans) driving expression of tamoxifen-inducible cre recombinase (cre/ERT2).

型号：GM-J#031327 -Cryorecovery

应用：Gdf5-Cre transgenic mice express cre recombinase from the mouse Gdf5 promoter in developing joints, including early joint interzones, adult articular cartilage, and the joint capsule. These mice are useful in studies of articular cartilage and arthritis.

型号：GM-J#031303 -Available

应用：Oxtr-T2A-Cre-D knock-in mice are designed to have Cre recombinase expression/activity directed by the endogenous oxytocin receptor promoter/enhancer sequences. In the brain, it is observed in restricted populations within the hippocampal formation, cortical subplate, striatum, thalamus, hypothalamus and medulla. Sparse, scattered expression is present in the cortex. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in OXTR-expressing cells.