型号：GM-J#031012 -Cryorecovery

应用：Cre-inducible iRep1 without Oct4-GFP mice, also called ROSA26-rtTA(neo); OKMSCh250, have the Cre-inducible ROSA26-rtTA(neo) allele and the TetO-OKMS-mCherry transgene from line 250 (OKMSCh250). Following Cre recombinase exposure, these mice allow doxycycline (dox)-inducible expression of a polycistronic OKMS cassette encoding four transcription factors (Oct4 [Pou5f1], Klf4, c-Myc [Myc] and Sox2) - which reprograms somatic cells that are derived from these animals to embryonic stem cell-like induced pluripotent stem cells (iPSCs). In addition, OKMS expression is accompanied by mCherry fluorescence.

型号：GM-J#031010 -Cryorecovery

应用：Cre-inducible iRep1 mice, also called Oct4-GFP; ROSA26-rtTA(neo); OKMSCh250, have the Oct4-GFP transgene, the Cre-inducible ROSA26-rtTA(neo) allele and the TetO-OKMS-mCherry transgene from line 250 (OKMSCh250). Following Cre recombinase exposure, these mice allow doxycycline (dox)-inducible expression of a polycistronic OKMS cassette encoding four transcription factors (Oct4 [Pou5f1], Klf4, c-Myc [Myc] and Sox2) - which reprograms somatic cells that are derived from these animals to embryonic stem cell-like induced pluripotent stem cells (iPSCs). In addition, OKMS expression is accompanied by mCherry fluorescence, and the Oct4-GFP transgene allows EGFP fluorescent determination of iPSC reprogramming/pluripotency status.

型号：GM-J#031008 -Available

应用：Aldh1l1-Cre/ERT2 BAC transgenic mice have tamoxifen-inducible Cre recombinase expression directed at high levels to the vast majority of astrocytes, with no detectable expression in neurons. These mice allow pan-astrocytic, specific and inducible genetic manipulations in vivo for studying astrocyte biology at different developmental stages in neural circuitry/synapses, behavior, disease and injury/trauma.

型号：GM-J#030970 -Cryorecovery

应用：A targeted knock-out of the Mapk10 (JNK3) gene ameliorates the spinal muscular atrophy phenotype associated with the FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/2J (Stock No. 005025) strain.

型号：GM-J#030961 -Available

应用：These LRRK2 G2019S knock-in mice carry two nucleotide substitution mutations in exon 41 of the Lrrk2 gene for the amino acid substitution G2019S which is associated with autosomal dominant, late-onset Parkinson's disease. These mice are suitable for use in applications related to the study of Parkinson's disease.

型号：GM-J#030952 -Available

应用：These Sun1-tagged mice, backcrossed to C57BL/6J, are used in the INTACT (isolation of nuclei tagged in specific cell types) method for immunopurification of nuclei. Cre-dependent removal of a floxed STOP cassette allows expression of the SUN1 fusion protein at the inner nuclear membrane in targeted cell types. These nuclei can be immunopurified with antibodies against GFP or MYC for transcriptional and epigenetic studies.

型号：GM-J#030926 -Cryorecovery

应用：Red5/R5 targeted knock-in/knock-out mice express tdTomato and humanized Cre recombinase from the mouse Il5 promoter in a variety of tissues.

型号：GM-J#030925 -Cryorecovery

应用：Catch22 is a knock-in/knock-out allele expressing tdTomato and humanized Cre recombinase from the mouse Il22 promoter in a variety of lymphocyte populations. Intestinal expression is primarily found in lymphoid-tissue inducer (LTi) cells of the solitary intestinal lymphoid tissues (SILT).

型号：GM-J#030867 -Cryorecovery

应用：Cre-mediated excision of a floxed stop cassette enables this Cre reporter strain to selectively express myc-tagged, membrane-anchored tdTomato fluorescent marker and hemagglutinin-tagged nuclear histone H2B-GFP from a CAG promoter.

型号：GM-J#030855 -Cryorecovery

应用：K5CreER;N1fl;N2fl;Ai9 mice (or K5-fl(N1/N2)-Ai9) are quadruple mutant animals with tamoxifen-inducible Cre recombinase expression directed to basal epithelial cell populations - resulting in Notch1/Notch2 knock-out and robust tdTomato fluorescence. These mice allow inducible genetic manipulations for studying Notch pathway disruption in epithelial tissues (e.g., epidermis, salivary gland, digestive tract, peripheral olfactory system) as well as UV-light skin damage and cancer biomarkers.