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  • B6;129S6-Chrna6tm1(flpo)

    产品型号:GM-J#034302 -Cryorecovery

    产品应用:Chrna6-IRES2-FlpO-WPRE-neo knock-in mice are designed to have optimized FLP recombinase expression directed to CHRNA6-expressing cells. FlpO expression/activity is observed in many locations throughout brain, including striatum, lateral geniculate nucleus, superior colliculus, Layer 5 of cortex, medulla, and cerebellum. These mice may be used to generate conditional mutations for studying α6-containing nicotinic acetylcholine receptors, for example, the role of dopaminergic neurons in nicotine addiction or as a possible therapeutic target for Parkinson's disease treatment.

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