产品型号：GM-J#036159 -Available

产品应用：Gba1E326K mice carry a CRISPR/Cas9-generated E344K knock-in in exon 8 of the mouse Gba1 (glucosidase, beta, acid 1) gene. This mutation corresponds to a human coding variant potentially associated with increased susceptibility to familial Parkinson's disease. Homozygotes show ~30-40% reduction in glucocerebrosidase (GCase) activity in whole brain tissue as well as a decrease in the total protein.