型号：GM-J#036499 -Cryorecovery

应用：Aire/CreER mice carry a transgene which expresses tamoxifen-inducible cre recombinase under the direction of the mouse Aire promoter/enhancer elements, primarily in medullary thymic epithelial cells (mTECs). These mice may be useful in the study of immune self-tolerance and mTEC development.

型号：GM-J#036482 -Available

应用：Gata1creERT2 BAC transgenic mice express erythroid lineage-specific, tamoxifen (Tx)-inducible cre recombinase from the mouse Gata1 (GATA binding protein 1) promoter in adult red blood cells.

型号：GM-J#036440 -Cryorecovery

应用：GckCre mice express improved Cre recombinase (icre) from the mouse Gck (glucokinase) promoter, enabling the excision of loxP-flanked sequences in GCK-positive regions of the brain (e.g. in neurons of the paraventricular thalamus (PVT)). This strain has been useful in Cre-dependent optogenetic and chemogenetic studies of glucose sensing and feeding behavior.

型号：GM-J#036431 -Cryorecovery

应用：Fgf15CretdT reporter mice express cre recombinase and tdTomato from the mouse Fgf15 (fibroblast growth factor 15) locus. Fluorescence detection reveals that tdTomato is expressed in all enterocytes lining the ileum villi, the main site of Fgf15 expression. In brain, no fluorescent signal is detected, suggesting that the level of tdTomato expression directed by the brain Fgf15 promoter is too low. Stereotactic injection of cre-dependent adeno associated viruses indicate that cre is expressed in the dorsomedial hypothalamus, perifornical area and medial habenula.

型号：GM-J#036418 -Cryorecovery

应用：Rosa26LSL-SV40-GFP mice have a CRISPR/cas9 generated insertion of a floxed STOP cassette and an SV40 T antigen coding region followed by an IRES-EGFP cassette inserted into the endogenous Gt(ROSA)26Sor locus. When crossed with a Cre recombinase expressing strain, removal of the floxed STOP cassette will result in SV40 and EGFP expression in cre expressing tissues. These mice may be useful for the generation of immortalized cell lines and fluorescent tracking of tumorigenesis.

型号：GM-J#036382 -Available

应用：Ms4a3Cre knock-in mice express Cre recombinase under direction of the Ms4a3 promoter in granulocyte-monocyte progenitor cells (GMPs).

型号：GM-J#036343 -Cryorecovery

应用：Apoc4-CreER knock-in mice have the endogenous apolipoprotein C-IV promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice are a Cre-lox tool allowing inducible Cre recombination in Apoc4-expressing cells/tissues (including hepatocytes of all zones surrounding the central vein), and may be useful in studying hepatocyte proliferation, organization and function.

型号：GM-J#036313 -Available

应用：cNdufs2- (MCI-Park) mice were generated to inactivate Ndufs2 (NADH:ubiquinone oxidoreductase core subunit S2) specifically in dopaminergic neurons (Ndufs2fl/fl DATIREScre/+). Ndufs2 encodes a protein that contributes to the ubiquinone-binding site of mitochondrial complex I (MCI). Homozygous knock-out animals manifest clear, levodopa-responsive parkinsonism that is attributable to MCI dysfunction. In contrast to conventional Parkinson's disease (PD) models in which dopamine (DA) is depleted rapidly throughout the basal ganglia, the staging of pathology in these mice enables an assessment of how regional deficits in DA release are coupled to behavior.

型号：GM-J#036307-JAX -Cryorecovery

应用：These microRNA cluster 31(miRlet7c-2/7b) conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in embryonic brain and spinal cord. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#036306-JAX -Cryorecovery

应用：These microRNA cluster 24(miR322) conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.