型号：GM-J#010611 -Available

应用：This strain expresses Cre recombinase from the endogenous Ighg1, immunoglobulin heavy constant gamma 1, locus. This strain represents an effective tool for generating tissue specific-targeted mutants that would be useful in the study of gene function in germinal center, class switched memory and plasma cells.

型号：GM-J#010590 -Cryorecovery

应用：A targeted insertion placed 2 kb 5' of the Igs1 (intergenic site, formerly Ubb) gene provides constitutive expression of a nuclear-localized beta-galactosidase/neomycin resistance protein reporter (NLS-beta-geo) in the absence of Cre-mediated recombination. Following Cre-mediated recombination, the NLS-beta-geo coding region is excised and a downstream open reading frame is expressed. When Cre-mediated recombination occurs in neurons, the amino terminal piece (tdTomato/TEVP, a 6xmyc epitope, a TEVP cleavage site) labels all axon and dendrites, and the carboxy-terminal portion (SV2B, GFP, 3xHA epitope) labels presynaptic structures. This reporter can be activated by cre recombinase in any cell in the body at any time in development.

型号：GM-J#010560 -Cryorecovery

应用：These mice possess loxP sites on either side of the Pou4f3 (POU domain, class 4, transcription factor 3) coding region followed by an alkaline phosphatase reporter. When crossed with a cre recombinase-expressing strain, the offspring express AP in the retina, dorsal root ganglia, and other cells/tissues.

型号：GM-J#010559 -Cryorecovery

应用：These mice possess loxP sites on either side of the Pou4f2 (POU domain, class 4, transcription factor 2) coding region followed by an alkaline phosphatase reporter. When crossed with a cre recombinase-expressing strain, the offspring express AP in the retina, several brain nuclei, dorsal root ganglia, trigeminal ganglion, and other cells/tissues.

型号：GM-J#010558 -Cryorecovery

应用：These mice possess loxP sites on either side of the Pou4f1 (POU domain, class 4, transcription factor 1) coding region followed by an alkaline phosphatase (AP) reporter. When crossed with a cre recombinase-expressing strain, offspring express AP in the retina, several brain nuclei, dorsal root ganglia, trigeminal ganglion, and other cells/tissues.

型号：GM-J#010557 -Cryorecovery

应用：These R26rtTACreER mice have a CreERT, reverse tetracycline trans-activator (rtTA), and Tet-responsive element (TRE) targeted to the mouse Gt(ROSA)26Sor gene to create a gene expression tool with two independent layers of pharmacologic control and a widespread pattern of activity. In this construct, expression of tamoxifen-sensitive CreERT is under the control of rtTA. Upon administration of doxycycline, rtTA activates transcription of the CreER coding region. This enhances the dynamic range of CreER and enables sparse labeling in situations where reduced recombination efficiency facilitates behavioral, morphological or functional studies of modified cells among populations of unmodified neighbors.

型号：GM-J#010550 -Cryorecovery

应用：The mouse Penk (preproenkephalin) promoter drives expression of the C. elegans glutamate-gated chloride channel beta subunit and cre/ESR1. When crossed with a strain containing a loxP site-flanked sequence of interest, the flanked sequences are deleted in the offspring upon administration of tamoxifen.

型号：GM-J#010536 -Available

应用：These transgenic mice express Cre recombinase under the control of the mouse Purkinje cell protein (Pcp2). Cre recombinase expression is detected in Purkinje cells of the cerebellar folia and retinal bipolar cells. This strain represents an effective tool for generating tissue specific-targeted mutants that would be useful in neurological research.

型号：GM-J#010531 -Cryorecovery

应用：These targeted mutant mice carry tamoxifen-inducible Cre under the transcriptional control of the mouse Bmi1 (Bmi1 polycomb ring finger oncogene) promoter. When crossed with a strain containing a loxP-flanked sequence of interest, the offspring are useful for generating tamoxifen-induced, Cre-mediated targeted deletions, and when crossed with a floxed reporter strain, lineage tracing of Bmi1-expressing cells is possible.

型号：GM-J#010530 -Cryorecovery

应用：This Pax7 knock-in strain may be useful in studies of alveolar rhabdomyosarcoma and embryonic myogenesis.