型号：GM-J#010988 -Cryorecovery

应用：These Cyp11a1-GC mutant mice have a Cre-mediated recombination system and could be useful in studies of genitourinary system development.

型号：GM-J#010987 -Cryorecovery

应用：These Sox18-GCE mutant mice have a tamoxifen inducible Cre-mediated recombination system. A GFP-Cre/ERT2 cassette (GCE) was inserted into the Sox18, SRY-box containing gene 18, locus. Following tamoxifen administration green fluorescence is detected in the kidneys and ovary of E15.5 heterozygous embryos and Cre recombinase activity is detected in a low percentage of cells in the kidney from E15.5 heterozygous embryos. This mutant mouse strain may be useful in studies of genitourinary system development.

型号：GM-J#010985 -Cryorecovery

应用：These Klf3-GCE mutant mice have a tamoxifen inducible Cre-mediated recombination system. A GFP-Cre/ERT2 cassette (GCE) was inserted into the endogenous locus. Following tamoxifen administration weak green fluorescence is detected in the back, limbs and kidney of E15.5 heterozygous embryos while Cre recombinase activity is detected in kidney from E15.5 heterozygous embryos. This mutant mouse strain may be useful in studies of genitourinary system development.

型号：GM-J#010912 -Available

应用：The Wt1CreERT2 knock-in/knock-out allele both abolishes Wilms tumor 1 homolog gene function and directs expression of the CreERT2 fusion protein to proepicardium and epicardium by the Wt1 promoter/enhancer elements. As Wt1 is expressed in the developing genitourinary system and in the mesothelia overlying most visceral organs, these mutant mice are useful as a tamoxifen-inducible Cre-lox tool for lineage-tracing/marking Wt1-expressing cells for studying cardiomyocytes in the developing heart.

型号：GM-J#010911 -Cryorecovery

应用：The Wt1GFPCre knock-in allele in these mice both abolishes Wilms tumor 1 homolog gene function and expresses an EGFPCre fusion protein directed to proepicardium and epicardium by the Wt1 promoter/enhancer elements. As Wt1 is expressed in the developing genitourinary system and in the mesothelia overlying most visceral organs, these mutant mice may be useful as fluorescent/Cre-lox tools for lineage-tracing/marking Wt1-expressing cells for studying cardiomyocytes in the developing heart.

型号：GM-J#010910 -Cryorecovery

应用：Cst-T2A-Cre (Cort-T2A-Cre) mice have Cre recombinase expression directed to Cort-expressing cells (CST positive neurons) by the endogenous promoter/enhancer elements of the cortistatin locus.

型号：GM-J#010908 -Available

应用：Vip-IRES-Cre mice have Cre recombinase expression directed to Vip-expressing cells by the endogenous promoter/enhancer elements of the vasoactive intestinal polypeptide locus. Cre activity is detected in the neocortex, hippocampus, olfactory bulb, suprachiasmatic nuclei, and other discrete midbrain and brainstem regions. These mice may be useful to study neural GABAergic circuits throughout the mammalian brain.

型号：GM-J#010803 -Cryorecovery

应用：A C57BL/6J congenic version of this strain is available as Stock No. 028020.

型号：GM-J#010802 -Available

应用：Gad2-IRES-Cre knock-in mice have Cre recombinase expression directed to GAD2 positive neurons. These mice may be used to generate conditional mutations for studying GAD2 cell populations.

型号：GM-J#010799 -Available

应用：These double transgenic homozygous mice (dbl-PAC-Tg(SNCAA53T);Snca-/- mice) harbor a Snca knock-out allele and two independently inserted transgenes encoding the human A53T-mutant α-synuclein associated with autosomal dominant Parkinson's disease. The very early gastrointestinal dysfunction in the absence of major central nervous system pathology in dbl-PAC-Tg(SNCAA53T);Snca-/- mice mimics what is seen early in human Parkinson's disease, when enteric nervous system dysfunction may precede the more classical motor symptoms by years to decades.