型号：GM-J#016097 -Cryorecovery

应用：This CAC5 transgenic mouse strain expresses Cre recombinase under the control of the mouse Car1 promoter and may be useful in generating large intestine specific-targeted mutants for colon disease research. It has been determined that the transgene inserted on chr 8 (details below); there are no genes annotated in the region of the insertion.

型号：GM-J#015855 -Available For Registering Interest

应用：This strain is currently unavailable due to replenishing of cryopreserved stocks. Interested customers who register interest will be contacted when the strain is again available.

型号：GM-J#015854 -Cryorecovery

应用：These Fox L2-GCE mutant knock in mice utilize a tamoxifen inducible Cre-mediated recombination system and may be useful in studies of genitourinary system development.

型号：GM-J#015833 -Cryorecovery

应用：This floxed Rims2 (regulating synaptic membrane exocytosis 2) mutation strain enables cre-mediated excision of the α, β, and γ isoforms of the gene and may be useful in studies of synaptic neurotransmission.

型号：GM-J#014647 -Available

应用：These Pdx-Cre transgenic mice express Cre recombinase under the control of the mouse Pdx1 promoter and may be useful for generating pancreas-specific conditional mutations.

型号：GM-J#014643 -Cryorecovery

应用：These Chm:Cre transgenic mice express cre under the control of the baboon CMA1, chymase 1, mast cell, promoter and may be useful for generating conditional mutations for studying gain/loss of function or fate mapping in resident mast cell lineages of the colon and lung.

型号：GM-J#014600 -Cryorecovery

应用：These transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse I12b enhancer element of Dlx1/2, and may be useful for generating temporal conditional mutations for studying gain or loss of function and/or fate mapping in Dlx1/2-expressing forebrain tissues, including interneurons of the olfactory bulb and neocortex.

型号：GM-J#014554 -Available

应用：The SERT-cre (SERTcre) "knock-in" allele has a nuclear-localized Cre recombinase inserted just upstream of the first coding ATG of the serotonin transporter gene (Slc6a4; SERT or 5-HTT). This was designed to both abolish gene function and place Cre recombinase expression under the control of the SERT promoter/enhancer elements.

型号：GM-J#014552 -Cryorecovery

应用：The Nkx2.1-CreER (or Nkx2.1-CreERT2) knock-in/knock-out allele expresses a tamoxifen-inducible Cre recombinase from the endogenous promoter/enhancer elements of the NK2 homeobox 1 (Nkx2-1) gene. When induced, CreERT2 expression recapitulates endogenous Nkx2-1 expression, mainly in the medial and caudal ganglionic eminences of the basal ganglia and the preoptic area. These mice may be useful in studying the role of medial ganglionic eminences progenitor cells in GABAergic neuron development, as well as lung, thyroid, and pituitary development.

型号：GM-J#014551 -Cryorecovery

应用：The Dlx1-CreERT2 knock-in allele was designed to both abolish distal-less homeobox 1 (Dlx1) gene function and direct CreERT2 fusion protein expression to Dlx1 positive neurons (including cortical GABAergic neurons, striatal neurons, and olfactory neurons) by the endogenous Dlx1 promoter/enhancer elements. Cre-ERT2 fusion gene activity is inducible by tamoxifen administration.