型号：GM-J#016223 -Available

应用：Phox2b-Cre BAC transgenic mice have Cre recombinase expression directed primarily to the hindbrain by the Phox2b promoter/enhancer regions, and may be used to generate conditional mutations for studying neuronal cell types expressing or depending on the Phox2b transcription factor. Specifically, these mice may be useful for studying human respiratory disease, central chemoreceptive neurons in the retrotrapezoid nucleus, respiratory rhythmogenesis, and autonomic nervous system dysregulation (such as congenital central hypoventilation syndrome (CCHS) or Ondine-Hirschsprung disease).

型号：GM-J#016222 -Cryorecovery

应用：This Id2-CreERT2 knock-in allele was designed to both abolish Id2 gene function and direct CreERT2 fusion protein expression from the endogenous Id2 promoter/enhancer elements. Cre-ERT2 fusion gene activity is inducible by tamoxifen administration.

型号：GM-J#016210 -Cryorecovery

应用：LRRK2 KO2 mice have with exons 29-30 of the Lrrk2 gene deleted. These mice may be useful in studying the cellular function of LRRK2 during aging in the maintenance of protein homeostasis and, specifically, α-synuclein through the regulation of protein degradation pathways.

型号：GM-J#016209 -Cryorecovery

应用：LRRK2 KO1 mice have the promoter and exon 1 of the Lrrk2 gene deleted. These mice may be useful in studying the cellular function of LRRK2 during aging in the maintenance of protein homeostasis.

型号：GM-J#016207 -Cryorecovery

应用：Mecp2*A140V mice contain the amino acid mutation A140V in exon 4 of the endogenous methyl CpG binding protein 2 gene, and loxP sites flanking exons 3-4. These mice may be useful for studying impaired neurodevelopmental maturation associated with human RTT.

型号：GM-J#016198 -Cryorecovery

应用：The calcium/calmodulin-dependent protein kinase II alpha (sometimes referred to as CaMKII-tTA) transgene in these mice is a "Tet-Off" system that allows inducible control over expression of genes in forebrain neurons, and may be useful in studying brain disorders such as Alzheimer's disease, Parkinson's disease, or other neurodegenerative diseases.

型号：GM-J#016123 -Available

应用：This knock-out mutation strain lacks exons 1 through 4 of the Snca (synuclein, alpha) gene.

型号：GM-J#016122 -Not Available At Jax

应用：Stock No. 016122 has been discontinued. Researchers can assemble this double mutant strain by breeding Stock No. 016120 mice and Stock No. 016121 mice together.

型号：GM-J#016121 -Cryorecovery

应用：These knock-out mice lack exons 39-40 of the leucine-rich repeat kinase 2 (Lrrk2) gene and may be useful for studying the role of Lrrk2 in the progression of Parkinson's Disease.

型号：GM-J#016120 -Cryorecovery

应用：These Lrrk1 knock-out mice may be useful for studying the role of Lrrk1 in the progression of Parkinson's Disease.