型号：GM-J#017320 -Available Now

应用：PV-Cre knock-in (Pvalb-IRES-Cre) mice express Cre recombinase in parvalbumin-expressing neurons (such as interneurons in the brain and proprioceptive afferent sensory neurons in the dorsal root ganglia), without disrupting endogenous Pvalb expression. These mice may be useful in studying neuronal development, differentiation, and physiology.

型号：GM-J#017310 -Cryorecovery

应用：Mice hemizygous for the BAC Hsd17b1-icreERT2 transgene are viable, fertile, and normal in size with iCre-ERT2 expression directed by the hydroxysteroid (17-beta) dehydrogenase 1 (Hsd17b1) promoter/enhancer regions within the BAC transgene. These mice may be useful for studying gene function in ovarian granulose cells.

型号：GM-J#017009 -Available Now

应用：Nfe2l2tm1Ywk (NRF2) knockout mice may be useful for studying oxidative stress in the pathogenesis of age-related macular degeneration, diabetes, Parkinson's disease, and other inflammatory degenerative diseases as well as studies of cancer, multiple sclerosis, liver cirrhosis, atherosclerosis, injury and wound healing, and more.

型号：GM-J#017001 -Cryorecovery

应用：These mice carry a knock-out mutation of the Plk2 gene. Homozygotes exhibit a decrease in soluble alpha synuclein phosphorylation in the brain and may be useful in studies of Parkinson's Disease.

型号：GM-J#017000 -Cryorecovery

应用：These transgenic mice express the mutant human SNCA, synuclein, alpha (non A4 component of amyloid precursor), with the E46K mutation in exon 3. Hemizygous mice display age dependent synaptic degeneration in the striatum. This line may be a useful model for studies of Parkinson's Disease.

型号：GM-J#016976 -Cryorecovery

应用：These transgenic mice carry a humanized synuclein mutant (SNCA*A53T) gene regulated by a tetracycline operator. When mated to a mutant strain expressing tTA, expression of SNCA*A53T protein may be regulated with the tetracycline analog doxycycline in the double mutant offspring.

型号：GM-J#016963 -Available

应用：Vglut2-ires-Cre knock-in mice have Cre recombinase expression directed to excitatory glutamatergic neuron cell bodies, without disrupting endogenous vesicular glutamate transporter 2 expression. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to glutamatergic neurons.

型号：GM-J#016962 -Cryorecovery

应用：A congenic version of this strain is available as Stock No. 028862.

型号：GM-J#016961 -Available

应用：Foxp3EGFP-cre-ERT2 mutant mice contain an internal ribosome entry site (IRES) and an enhanced green fluorescent protein (EGFP) fused to a CreERT2 fusion gene downstream of the internal stop codon of the forkhead box P3 (Foxp3) gene. These mice may be useful for studying lineage stability and genetic mapping of regulatory T cells.

型号：GM-J#016936 -Cryorecovery

应用：mThy1-hSNCA mice contain a transgene consisting of the mouse thymus cell antigen 1 (Thy-1) promoter directing expression of the human α-synuclein (SNCA) gene. These mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration elicited by the toxic effects of aggregation and somatic accumulation of SNCA.