型号：GM-J#016584 -Cryorecovery

应用：These TPH2-iCreER transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Tph2 promoter and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping of Tph2 expressing neurons in the raphe nucleus.

型号：GM-J#016583 -Cryorecovery

应用：These DAT-iCreER transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Slc6a3 promoter region and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping of dopaminergic neurons in the substantia nigra and locus coeruleus, as well for studying drug addiction, Parkinson's disease and Attention Deficit-Hyperactivity Disorder (ADHD).

型号：GM-J#016582 -Cryorecovery

应用：These VGAT-iCreER transgenic mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Slc32a1 promoter region and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping throughout the brain in neurons that structurally resemble interneurons.

型号：GM-J#016576 -Cryorecovery

应用：R1441C-LRRK2 transgenic mice have a minimal cytomegalovirus (CMV) enhancer and human platelet derived growth factor, B polypeptide (PDGFB) promoter/enhancer elements driving expression of a mutated full length human leucine-rich repeat kinase 2 (LRRK2*R1441C) cDNA. These mice may be useful for studying Parkinson's disease pathogenesis and neurodegeneration elicited by the dominant toxic effects of mutant LRRK2*R1441G expression.

型号：GM-J#016575 -Cryorecovery

应用：G2019S-LRRK2 transgenic mice have a minimal cytomegalovirus (CMV) enhancer and human platelet derived growth factor, B polypeptide (PDGFB) promoter/enhancer elements driving expression of a mutated full length human leucine-rich repeat kinase 2 (LRRK2*G2019S) cDNA. These mice may be useful for studying Parkinson's Disease pathogenesis and neurodegeneration elicited by the dominant toxic effects of mutant LRRK2*G2019S expression.

型号：GM-J#016566 -Cryorecovery

应用：HCN1 knock-out mice lack the p region and S6 transmembrane (pore-S6) domain of the hyperpolarization-activated, cyclic nucleotide-gated K+ 1 (Hcn1) gene. This mutant mouse strain may be useful in studies of learning, memory, neurophysiology, and Parkinson's Disease.

型号：GM-J#016539 -Cryorecovery

应用：These Cripto2loxP mice possess a loxP-sites flanking exons 3-5 of the cripto, EGF-CFC family member (Cripto formerly Tdgf1) gene. This strain may be useful for studying embryonic development and tumor growth.

型号：GM-J#016261 -Available

应用：Nestin-Cre/ERT2 transgenic mice express tamoxifen-inducible Cre recombinase in adult and developing mouse brain, including neuronal and glial cell precursors.

型号：GM-J#016241 -Cryorecovery

应用：This Col1a1-CreERT2 mutant mouse strain carries a transgene with tamoxifen inducible Cre recombinase and may be useful for generating osteoblast and odontoblast specific targeted mutants for studies of bone physiology and homeostasis.

型号：GM-J#016236 -Cryorecovery

应用：TopCreERT2 transgenic mice express a CreERT2 fusion protein under the control of three copies of a T cell specific transcription factor/lymphoid enhancer-binding factor 1 (TCF/Lef1) response element and a c-fos minimal promoter. This strain may useful for studying the Wnt signaling pathway.