型号：GM-J#029679 -Cryorecovery

应用：Ai155 Optopatch3 mice, an improved version of Optopatch2, are a sensitive, fast optogenetic tool for targeted, simultaneous optical perturbation and optical measurement of membrane voltage. Conditional expression is dependent on cre-mediated excision of a floxed Stop cassette.

型号：GM-J#029677 -Cryorecovery

应用：Conditional expression of Optopatch2 (an optogenetic actuator/indicator) is under the control of a tetracycline response element (TRE; tetO) and floxed Stop integrated in the Igs7 (TIGRE) locus. Functionality of Optopatch2 requires the expression of tTA as well as cre recombinase-mediated excision of the floxed Stop. This is line Ai141.

型号：GM-J#029664 -Cryorecovery

应用：MafB-mCherry-Cre knock-in mice express a FLAG-tagged-mCherry fluorescent protein and a Cre Recombinase sequence under the direction of the MafB promoter. These mice are useful for lineage tracing.

型号：GM-J#029656 -Cryorecovery

应用：Slc6a11-Cre/ERT2 BAC transgenic mice have tamoxifen-inducible Cre recombinase expression directed at moderate levels to astrocytes and neurons. These mice allow inducible genetic manipulations in vivo for studying astrocyte and neuron biology of GAT3+ cells.

型号：GM-J#029655 -Cryorecovery

应用：Aldh1l1-Cre/ERT2 BAC transgenic mice have tamoxifen-inducible Cre recombinase expression directed at high levels to the vast majority of astrocytes, with no detectable expression in neurons. These mice allow pan-astrocytic, specific and inducible genetic manipulations in vivo for studying astrocyte biology at different developmental stages in neural circuitry/synapses, behavior, disease and injury/trauma.

型号：GM-J#029645 -Available

应用：These targeted mutant mice express tamoxifen-inducible cre recombinase from the mouse Postn gene. Expression is restricted to myofibroblasts that have undergone tissue damage (e.g. a myocardial infarction event).

型号：GM-J#029633 -Available

应用：CAGs-LSL-RIK (or Rosa26-CAGs-LSL-RIK) knock-in has a CAG promoter and loxP-flanked STOP cassette upstream of the third-generation reverse tetracycline-regulated transactivator gene (rtTA3), IRES sequence and the monomeric far-red fluorescent protein mKate2, all inserted into the Gt(ROSA)26Sor locus. These mice are a Cre recombinase-dependent, Tet-On and fluorescent tool strain - following removal of the floxed-STOP cassette, they allow dox-conditional expression of TRE promoter-driven target genes in conjunction with mKate2 fluorescence.

型号：GM-J#029626 -Cryorecovery

应用：The Lck-GCaMP6fflox (or R26-Lck-GCaMP6fflox) knock-in mice have Cre-dependent expression of a plasma membrane-targeted GCaMP6f. Lck-GCaMP6f is a detector of single neuronal action potentials with fast response kinetics. It has an Lck-tag to improve its ability to reveal calcium signals in near membrane regions and fine processes (e.g., astrocyte processes). After Cre exposure, bright GCaMP6f fluorescence is observed following calcium binding (such as neuronal activation).

型号：GM-J#029619 -Cryorecovery

应用：IL-2cre knock-in mice express Cre recombinase under the direction of the IL-2 promoter. These mice are useful for labelling CD4+ T cells in lung, bone marrow, spleen, Peyer’s Patches, mesenteric lymph nodes, and intraepithelial lymphocytes and lamina propria of small intestine.

型号：GM-J#029617 -Cryorecovery

应用：The CAGs-LSL-rtTA3 (or Rosa26-CAGs-LSL-rtTA3) knock-in allele has a CAG promoter and loxP-flanked STOP cassette upstream of the third-generation reverse tetracycline-regulated transactivator gene (rtTA3), all inserted into the Gt(ROSA)26Sor locus. These mice are a Cre recombinase-dependent, Tet-On tool strain - following removal of the floxed-STOP cassette, they allow dox-conditional expression of TRE promoter-driven target genes.