型号：GM-J#029617 -Cryorecovery

应用：The CAGs-LSL-rtTA3 (or Rosa26-CAGs-LSL-rtTA3) knock-in allele has a CAG promoter and loxP-flanked STOP cassette upstream of the third-generation reverse tetracycline-regulated transactivator gene (rtTA3), all inserted into the Gt(ROSA)26Sor locus. These mice are a Cre recombinase-dependent, Tet-On tool strain - following removal of the floxed-STOP cassette, they allow dox-conditional expression of TRE promoter-driven target genes.

型号：GM-J#029594 -Not Available At Jax

应用：Stock No. 029594 has been discontinued. We recommend B6.Cg-Tg(Dmp1-cre/ERT2)0022Pdp/IkalJ (Stock No. 032757) as a replacement.

型号：GM-J#029588 -Cryorecovery

应用：Ntng2-IRES2-Cre-D knock-in mice are designed to have Cre recombinase expression directed to netrin G2-expressing Cre recombinase expression and activity largely recapitulates the endogenous Ntng2 gene - it is enriched in claustrum but relatively sparse in nearby structures (anterior dorsal nucleus, taenia tecta and endopiriform nucleus). These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to this netrin G protein, such as axon guidance.

型号：GM-J#029587 -Cryorecovery

应用：Gnb4-IRES2-Cre-D knock-in mice are designed to have Cre recombinase expression directed to guanine nucleotide binding protein (G protein) beta 4-expressing cells. Cre recombinase expression and activity largely recapitulates the endogenous Gnb4 gene - it is enriched in claustrum but relatively sparse in nearby structures (endopiriform nucleus and deep insular cortex). These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to this G protein.

型号：GM-J#029582 -Cryorecovery

应用：This CRISPR/Cas9 generated mutant of the Trpv4 gene carries a cre/ERT2 knock-in mutation.

型号：GM-J#029575 -Cryorecovery

应用：These Hmga2CK mice possess pairs of variant loxP sites on either side of exon 2 and a SA-GFP-SD cassette (in reverse orientation) in intron 2 of the Hmga2 gene. Cre-recombination puts GFP under the control of all of the endogenous regulatory elements of endogenous Hmga2 (while also creating a null allele). Applications may include growth, development, transcriptional regulation and cancer metastasis.

型号：GM-J#029567 -Available

应用：This Col1a2 Cre-ER mutant mouse strain carries a transgene with tamoxifen inducible Cre recombinase and may be useful for generating fibroblast specific targeted mutants for studies of fibrotic diseases, wound healing and connective tissue physiology, as well as fibroblast lineage fate mapping.

型号：GM-J#029566 -Cryorecovery

应用：These Isl1 MerCreMer knock-in mice express a tamoxifen-inducible cre recombinase from the endogenous promoter/enhancer elements of the Isl1 gene. When induced, cre activity is observed in Isl1 expressing cells in embryos. These mice may be useful for generating conditional mutations for studying cell lineages during development of the nervous system, heart, pituitary gland, pancreas and stomach.

型号：GM-J#029498 -Cryorecovery

应用：This CRISPR/Cas9 generated mutant of the Gfra3 gene carries a cre/ERT2 knock-in mutation.

型号：GM-J#029490 -Cryorecovery

应用：The doxycycline-regulated Nkx2.5 enhancer-eGFP/Cre transgenic mice have the cardiac-specific mouse NK2 homeobox 5 promoter/enhancer sequences directing dox-controllable expression of eGFP/Cre fusion protein to early heart progenitor cells (cardiomyoblasts) from embryonic day (E)7.5-E11.5. These Nkx2.5 enh-GFP-Cre transgenic mice allow Nkx2.5+ cardiomyoblast fluorescent labeling (cell isolation by FACS) and lineage tracing in a doxycycline-regulated fashion.