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  • 型号:GM-J#030216 -Cryorecovery

    应用:Ai136(TITL-ReaChR-YFP)-D (also called Ai136D) mice are a Cre/Tet-dependent, optogenetic line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Following Cre-mediated removal of the STOP cassette, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of the channelrhodopsin/EYFP fusion protein (ReaChR/EYFP). Subsequent illumination of ReaChR-expressing (EYFP fluorescent) cells with orange-to-red light leads to reversible photostimulation of action potential firing/neural activity in these cells.

    2024-11-09 点击次数:0

    型号:GM-J#030215 -Available

    应用:The Amigo2-Cre BAC transgene has the adhesion molecule with Ig like domain 2 promoter/enhancer regions directing Cre recombinase expression predominantly to CA2 pyramidal neurons in adult mice. These mice may be useful for recombination of lox-flanked (floxed) alleles in studying neuronal function (sociocognitive memory formation and mental retardation) PDK1-AKT pathway regulation (angiogenesis and anti-apoptosis), T-cell modulation and multiple sclerosis.

    2024-11-09 点击次数:0

    型号:GM-J#030213 -Cryorecovery

    应用:Ai133(TITL-ssAPEX2tm)-D (also called Ai133D) mice are a Cre/Tet-dependent, substrate-dependent reporter line - created by targeted insertion of floxed-STOP-APEX2 at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassette by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of APEX2 - an engineered peroxidase with improved catalytic efficiency that functions as an electron microscopy tag and a promiscuous labeling enzyme for live-cell proteomics.

    2024-11-09 点击次数:0

    型号:GM-J#030206 -Cryorecovery

    应用:The RC::FPSit dual-recombinase intersectional allele has a frt-flanked STOP and loxP-flanked STOP that prevent transcription of synaptophysin-EGFP fusion protein and tdTomato. Exposure to FLP and Cre recombinase results in strong EGFP expression enriched at the synapse/synaptic vesicle (axonal boutons [terminal and en passant]) of the neuron subtype(s) defined by the overlap of FLP/Cre expression.

    2024-11-09 点击次数:0

    型号:GM-J#030201 -Available

    应用:PDGFRβ-P2A-CreERT2 mice express tamoxifen-inducible Cre recombinase under the direction of the murine platelet derived growth factor receptor, beta polypeptide (Pdgfrb) promoter. They are useful for applications requiring tamoxifen-induced deletion of floxed sequences in vascular pericytes.

    2024-11-09 点击次数:0

    型号:GM-J#030197 -Cryorecovery

    应用:Pdyn-T2A-CreERT2-D knock-in mice express tamoxifen-inducible Cre recombinase from the endogenous prodynorphin promoter/enhancer elements. When induced, CreERT2 expression/activity is observed mainly in central amygdalar nucleus, paraventricular hypothalamic nucleus, nucleus accumbens, caudoputamen and cortex. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping related to this precursor of opioid peptides.

    2024-11-09 点击次数:0

    型号:GM-J#030189 -Cryorecovery

    应用:BDNF-2A-Cre knock-in mice are designed to have Cre recombinase expression directed to brain derived neurotrophic factor-expressing cells. Cre activity recapitulates that of the endogenous Bdnf gene in the brain. These mice may be used to generate conditional mutations for studying this neuropeptide/neurotrophin in aspects of neuronal function, including growth/differentiation of neurons and synapses, neurogenesis, synaptic transmission, learning, long-term memory, heat responses and human disease.

    2024-11-09 点击次数:0

    型号:GM-J#030182 -Cryorecovery

    应用:The Foxc2CreERT2 knock-in/knock-out allele was designed to both abolish endogenous gene function and allow the Foxc2 promoter/enhancer regions to direct tamoxifen-inducible Cre recombinase expression to lymphovenous valves, mural cells and bones of the developing embryo. These mice may be useful for tamoxifen-inducible recombination of lox-flanked (floxed) alleles in developmental studies (including kidney, lymphatic vessels, lymphovenous valves and heart).

    2024-11-09 点击次数:0

    型号:GM-J#030170 -Cryorecovery

    应用:Rosa26-lsl-mGCaMP3 mice express the membrane-associated fluorescent calcium indicator protein GCaMP3 after exposure to Cre recombinase. Following subsequent calcium binding (such as neuronal activation), bright EGFP fluorescence is observed.

    2024-11-09 点击次数:0

    型号:GM-J#030160 -Cryorecovery

    应用:Htr1a-IRES2-Cre-D knock-in mice are designed to have Cre recombinase expression/activity directed by the endogenous Htr1a promoter/enhancer sequences. In the brain, it is observed mainly in cortex, hippocampus and retro-hippocamal regions, as well as scattered neurons elsewhere in the brain. These mice may be used to generate conditional mutations for studying gain-or-loss of function and/or fate mapping in 5-HT1A-expressing cells, as well as serotonin receptor signaling and neurotransmission.

    2024-11-09 点击次数:0
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