型号：GM-J#030925 -Cryorecovery

应用：Catch22 is a knock-in/knock-out allele expressing tdTomato and humanized Cre recombinase from the mouse Il22 promoter in a variety of lymphocyte populations. Intestinal expression is primarily found in lymphoid-tissue inducer (LTi) cells of the solitary intestinal lymphoid tissues (SILT).

型号：GM-J#030867 -Cryorecovery

应用：Cre-mediated excision of a floxed stop cassette enables this Cre reporter strain to selectively express myc-tagged, membrane-anchored tdTomato fluorescent marker and hemagglutinin-tagged nuclear histone H2B-GFP from a CAG promoter.

型号：GM-J#030855 -Cryorecovery

应用：K5CreER;N1fl;N2fl;Ai9 mice (or K5-fl(N1/N2)-Ai9) are quadruple mutant animals with tamoxifen-inducible Cre recombinase expression directed to basal epithelial cell populations - resulting in Notch1/Notch2 knock-out and robust tdTomato fluorescence. These mice allow inducible genetic manipulations for studying Notch pathway disruption in epithelial tissues (e.g., epidermis, salivary gland, digestive tract, peripheral olfactory system) as well as UV-light skin damage and cancer biomarkers.

型号：GM-J#030759 -Cryorecovery

应用：Mc4r-2a-Cre knock-in mice may be useful for studying appetite control and obesity.

型号：GM-J#030757 -Available

应用：NDNF-ires-Cre knock-in mice (also called NDNF-Cre) are designed to have the endogenous neuron-derived neurotrophic factor promoter/enhancer driving Cre expression, as well as to retain endogenous Ndnf expression. These mice may be used to generate conditional mutations for studying gain-or-loss of function, fate mapping and/or circuit dissection of NDNF+ cell populations.

型号：GM-J#030744 -Available

应用：The constitutively-expressed R26-CAG-ASC-citrine allele has the Gt(ROSA)26Sor locus and CAG promoter directing widespread expression of a fluorescent adaptor fusion protein (ASC-citrine) that retains the function of endogenous ASC - forming assembled inflammasome complexes (specks) upon exposure to inflammasome activator(s) both in vitro and in vivo. These R26-CAG-ASC-citrine mice are a fluorescent reporter of inflammasome complex activation.

型号：GM-J#030743 -Cryorecovery

应用：The R26-CAG-LSL-ASC-citrine floxed allele has a CAG promoter and loxP-flanked STOP cassette upstream of the ASC-citrine fusion protein, all inserted into the Gt(ROSA)26Sor locus. Following removal of the floxed-STOP cassette, they express a fluorescent adaptor fusion protein (ASC-citrine) that retains the function of endogenous ASC - forming assembled inflammasome complexes (specks) upon exposure to inflammasome activator(s) both in vitro and in vivo. These R26-CAG-LSL-ASC-citrine mice are a Cre recombinase-dependent fluorescent reporter of inflammasome complex activation.

型号：GM-J#030681 -Cryorecovery

应用：GcgCreER2 mice express tamoxifen-inducible Cre recombinase under the direction of the glucagon promoter and in pancreatic alpha cells.

型号：GM-J#030676 -Cryorecovery

应用：TgCreERT2 mice express creERT2 directed by thyroglobulin (Tg) promoter on a PAC transgene. These mice may be useful for thyroid specific gene deletion.

型号：GM-J#030663 -Cryorecovery

应用：GcgiCre knock-in mice express a codon improved Cre recombinase gene in pancreatic alpha cells under the direction of the glucagon promoter.