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  • STOCK Notch1tm2Rko Notch2tm3Grid Gt(ROSA)26Sortm9(CAG-tdTomato)Hze Tg(KRT5-cre/E

    产品型号:GM-J#030855 -Cryorecovery

    产品应用:K5CreER;N1fl;N2fl;Ai9 mice (or K5-fl(N1/N2)-Ai9) are quadruple mutant animals with tamoxifen-inducible Cre recombinase expression directed to basal epithelial cell populations - resulting in Notch1/Notch2 knock-out and robust tdTomato fluorescence. These mice allow inducible genetic manipulations for studying Notch pathway disruption in epithelial tissues (e.g., epidermis, salivary gland, digestive tract, peripheral olfactory system) as well as UV-light skin damage and cancer biomarkers.

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