型号：GM-J#034648-JAX -Cryorecovery

应用：These microRNA 7-2 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. LacZ expression is observed in embryonic brain and spinal cord. This mutant mouse strain may be useful in studies of microRNA biology.

型号：GM-J#034623 -Cryorecovery

应用：These Pdx-Cre transgenic mice express Cre recombinase under the control of the mouse Pdx1 promoter on a congenic FVB/NJ background and may be useful for generating pancreas-specific conditional mutations.

型号：GM-J#034618 -Cryorecovery

应用：Nfe2l2tm1Ywk (NRF2) knock-out mice on the FVB/NJ background may be useful for studying oxidative stress in the pathogenesis of age-related macular degeneration, diabetes, Parkinson's disease, and other inflammatory degenerative diseases as well as studies of cancer, multiple sclerosis, liver cirrhosis, atherosclerosis, injury and wound healing, and more.

型号：GM-J#034516 -Cryorecovery

应用：DNAJC6 R857G knock-in mice carry an R857G (arginine to glycine) substitution in the Dnajc6 (DnaJ heat shock protein family (Hsp40) member C6) gene. Homozygous adult mice develop abnormal motor phenotypes. This strain may be useful for studying juvenile Parkinsonism.

型号：GM-J#034497 -Cryorecovery

应用：Gdf15nuGFP-CE knock-in/knock-out mice have a nuclear GFP reporter followed by an inducible Cre/ERT2 inserted into intron 1 of the growth differentiation factor 15 (Gdf15) gene. These mice can be used for lineage tracing in the kidney.

型号：GM-J#034473 -Cryorecovery

应用：The knock-in/knock-out Otx2CreERT2 allele replaces exons 1 and 2 of the orthodenticle homeobox 2 (Otx2) with a tamoxifen-inducible Cre-ERT2 under direction of the endogenous Otx2 promoter. These Otx2CreERT2 mice may be useful in studying neural development, retinal development, cellular proliferation, and medulloblastoma.

型号：GM-J#034470 -Cryorecovery

应用：Csf1r-iCre transgenic mice have codon optimized Cre recombinase (iCre) expression under the direction of the murine colony stimulating factor 1 receptor promoter (Csf1r). iCre recombinase expression is evident in immune cells, including macrophages, dendritic cells and bone marrow derived granulocytes.

型号：GM-J#034467 -Cryorecovery

应用：Ago2Halo-LSL knock-in mice have a HaloTag sequence followed by an in-frame loxP-flanked STOP-IRES-FLAG cassette upstream of the Ago2 first coding exon. Prior to introduction of Cre recombinase, this allele expresses a HaloTag protein and a Flag-Ago2 fusion protein. Cre recombinase exposure deletes the loxP-flanked STOP-IRES-FLAG cassette, which results in expression of the Halo-Ago2 fusion protein. These Ago2Halo-LSL mice allow Halo-enhanced Ago2 pulldown (HEAP) and are useful for identification of miRNA targets (miRNA-mRNA binding sites).

型号：GM-J#034424 -Available

应用：Sncg-IRES2-FlpO-neo knock-in mice are designed to have optimized FLP recombinase expression directed to gamma-synuclein-expressing cells. The donating investigator reports FlpO expression/activity in brain is strong in medulla, cerebellum, midbrain, pons, thalamus, hypothalamus and amygdala. These mice may be used to generate conditional mutations for studying neurodegenerative disorders (e.g., Parkinson's disease), behavior and learning, as well as tumor progression.

型号：GM-J#034408-JAX -Cryorecovery

应用：These double mutant (ht-PAC-305S) mice produce mutated human tau (MAPT), while no endogenous mouse tau (Mapt) is produced. S305S is associated with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP 17). This mutant mouse strain may be useful in studies of tau isoforms in neurodegenerative disease.