型号：GM-J#004608 -Cryorecovery

应用：These mice carry a spontaneous mutation at the Htra2 locus characterized by a basal ganglia disorder resulting in muscle atrophy, hunched posture, increased imbalance, chorea, dystonia, and progressive akinesis.

型号：GM-J#004600 -Cryorecovery

应用：Homozygotes for this transgene are not viable. Hemizygotes express Cre recombinase under the control of the human glial fibrillary acidic protein promoter (GFAP). When crossed with a strain containing loxP site flanked sequence of interest, Cre-mediated recombination results in tissue-specific deletion of the target, and recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. This mutant mouse strain represents an effective tool for generating central nervous system specific-targeted mutants.

型号：GM-J#004586 -Available

应用：These Vil1-cre mice express Cre recombinase in villus and crypt epithelial cells of the small and large intestines and may be useful in studies of intestinal organogenesis. In contrast to Villin-cre transgenic mice from founder line 1000 (Stock No. 021504) that are reported be absent of Cre recombinase activity in gonads, these Villin-cre transgenic mice from founder line 997 are reported to have a very low level (<1%) of cells with Cre recombinase activity in the testes.

型号：GM-J#004479 -Available Now

应用：M83 transgenic mice expresses the mutant human A53T alpha-synuclein under the direction of the mouse prion protein promoter. These mice may be useful in studying human neuronal alpha-synucleinopathies, such as familial Parkinson's Disease.

型号：GM-J#004453 -Cryorecovery

应用：These CAGGCre-ERTM mice express a fusion protein consisting of Cre recombinase joined to the ligand-binding domain of a modified mouse estrogen receptor and can be used to generate tamoxifen-induced, Cre-mediated targeted deletions when bred with strains carrying a floxed gene.

型号：GM-J#004426 -Cryorecovery

应用：These αGSU-cre transgenic mice express Cre recombinase and in combination with a floxed target gene results in deletion of the target gene in the anterior pituitary.

型号：GM-J#004337 -Cryorecovery

应用：Foxg1-Cre knock-in/knock-out mice express Cre recombinase from the endogenous Foxg1 locus specifically in the telencephalon and discrete head structures.

型号：GM-J#004322 -Cryorecovery

应用：These Mapk10 knock-out mice exhibit resistance to seizures and neuronal apoptosis caused by administration of excitotoxic glutamate-receptor agonist kainic acid.

型号：GM-J#004302 -Cryorecovery

应用：These mice carry a cre expression cassette, and are useful for deletion of loxP-flanked genes.

型号：GM-J#004192 -Cryorecovery

应用：Hypercholesterolemia can be reversed in these multiple-mutant (Reversa) mice. These mice are useful in studies relating to atherosclerosis.