型号：GM-J#003855 -Cryorecovery

应用：These NOD.RIP-cre, line5 transgenic mice express Cre recombinase and can be used in combination with a floxed target gene to create various pancreatic beta cell-specific gene knockouts.

型号：GM-J#003829 -Cryorecovery

应用：These Wnt-1/GAL4/cre-11 transgenic mice have expression of both Cre recombinase and the GAL4 transcriptional activator directed to midbrain and developing neural tube by the wingless-related MMTV integration site 1 (Wnt1) promoter/regulatory sequences. When Wnt-1/GAL4/cre-11 transgenic mice are bred to mice containing loxP site-flanked sequences, cre-mediated recombination results in deletion of the floxed sequences in the midbrain and developing neural tube of the resulting offspring.

型号：GM-J#003802 -Available

应用：This transgenic strain expresses Cre under the control of the Lck (lymphocyte protein tyrosine kinase) promoter, enabling thymocyte-specific excision of loxP-flanked sequences of interest. The Lck gene is primarily expressed by T lymphocytes and it plays a key role in the selection and maturation of developing T-cells in the thymus and in the activity of mature T-cells.

型号：GM-J#003771 -Available

应用：This strain is commonly known as nestin-Cre. Nestin promotor driven Cre recombinase is expressed in the central and peripheral nervous system, including neuronal and glial cell precursors. There are reports of Cre recombinase activity in a few isolated kidney and heart cells. Hemizygous nestin-cre mice exhibit mild hypopituitarism, growth retardation, impaired fear response, and a metabolic phenotype. Mice also show a strong impairment in the acquisition of both contextual- and cued-fear conditioning.

型号：GM-J#003755 -Cryorecovery

应用：This knock-in strain expresses Cre recombinase under the control of the endogenous Meox2 promoter with Cre recombinase active in early embryos. These mice can be utilized as a deleter strain for floxed genes and provide an alternative to tetraploid embryo analysis.

型号：GM-J#003734 -Cryorecovery

应用：The granzyme-B-Cre transgene is designed to have the human GZMB (granzyme B) promoter directing Cre recombinase expression to activated T cells.

型号：GM-J#003724 -Available

应用：EIIa-cre mice carry a cre transgene under the control of the adenovirus EIIa promoter that targets expression of Cre recombinase to the early mouse embryo, and are useful for germ line deletion of loxP-flanked genes.

型号：GM-J#003692 -Cryorecovery

应用：Homozygous null mice suffer from a reduction in total striatal dopamine and exhibit an attenuated locomotor response when given amphetamine. Observed phenotype suggests that Snca is an activity-dependent negative regulator of dopamine neurotransmission. These mice may be useful in studies relating to Parkinson's disease.

型号：GM-J#003651 -Available

应用：cre expression in these mice is controlled by regulatory sequences from the mouse zona pellucida 3 (Zp3) promoter, which normally directs expression exclusively in the growing oocyte prior to the completion of the first meiotic division. This strain would be useful for deleting a floxed sequence specifically in the female germ line.

型号：GM-J#003574 -Available Now

应用：Alb-cre mice are useful for deletion of loxP-flanked genes in the liver. Please note: this strain also is available on the 129 background (Stock No. 035593).