型号：GM-J#005549 -Cryorecovery

应用：Cre recombinase expression is detected in the dorsal neural tube and somites of early embryos and in neural crest and somite derivatives of later gestation embryos. This knock-in mutant mouse strain represents a model that may be useful in studies of development and lineage mapping of neural crest and somite derivatives

型号：GM-J#005438 -Cryorecovery

应用：These Z/RED transgenic mice express beta-galactosidase (lacZ) under the control of the chicken beta actin promoter coupled with the cytomegalovirus (CMV) immediate early enhancer. When crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with red fluorescent protein (DsRed*MST) expression in tissues expressing Cre recombinase. This double reporter system makes it possible to distinguish a lack of reporter expression from a lack of Cre recombinase expression while providing a means to assess Cre excision activity in live animals and cells.

型号：GM-J#005359 -Available

应用：This strain is commonly known as T29-1. CaMKIIα-Cre line T29-1 transgenic mice have the mouse calcium/calmodulin-dependent protein kinase II alpha (Camk2a) promoter driving Cre recombinase expression in the forebrain, including the CA1 pyramidal cell layer of the hippocampus. See strain description below for additional information. This strain is useful is examining synaptic plasticity and Long Term Potentiation (LTP) in hippocampal networks.

型号：GM-J#005249 -Cryorecovery

应用：These transgenic mice express a RU 486-inducible cre recombinase driven by the mouse keratin complex 1, acidic, gene 15 promoter. When induced, cre activity is observed in epithelial stem cells in the bulge region of the hair follicle. These mice may be useful to study epithelial and hair follicle stem cells lineage.

型号：GM-J#005130 -Available

应用：When these mice are used in conjunction with a Cre recombinase-expressing strain, successful Cre-mediated excision results in the constitutive expression of the Smo/EYFP fusion gene (monitored by using EYFP-specific fluorescence protocols) and unrestrained Hedgehog signaling in Cre-expressing tissues. As examples, this strain may be useful in studies of tumorigenic potential in the hedgehog pathway, progenitor cell involvement in the development of medulloblastomas, craniofacial development, thalamic development, and of oligodendrocyte maturation and CNS myelination when used in combination with specific cre-expressing strains.

型号：GM-J#005125 -Available

应用：This strain serves as a Cre reporter strain. When used in conjunction with a Cre recombinase-expressing strain, successful Cre-mediated excision is indicated by luciferase expression in Cre-expressing tissues.

型号：GM-J#005107 -Available

应用：These transgenic mice have a tamoxifen inducible Cre-mediated recombination system driven by the human keratin 14 (KRT14) promoter, which is active in dividing cells of epidermis and some other stratified squamous epithelia. When crossed with a strain containing a loxP site flanked sequence of interest, the offspring can be used to generate tamoxifen-induced, Cre-mediated targeted keratinocyte-specific deletions. This strain may be useful for studying somatic mutations of the skin, including squamous and basal cell carcinomas.

型号：GM-J#005105 -Cryorecovery

应用：These Chx10 BAC mice express a transgene containing EGFP and human placental alkaline phosphatase with reporter activity being seen in a subset of Müller glial cells.

型号：GM-J#005069 -Cryorecovery

应用：The FABP4-Cre transgene has a mouse Fabp4 promoter directing expression of Cre recombinase. These FABP4-Cre transgenic mice are a Cre-lox tool useful for deletion of floxed sequences in brown and white adipose tissue.

型号：GM-J#004987 -Cryorecovery

应用：These NOD.RIPCre6 mice express cre recombinase in pancreatic beta cells.