型号：GM-J#009688 -Cryorecovery

应用：Dopamine-deficient (DA-deficient, DA-/-, or DD) mice are homozygous for the TH mutant allele and heterozygous for the DBH-TH mutant allele (Th-/-;DbhTh/+). While no expression from the TH mutant allele is observed in any tissues (resulting in deficiency of both dopamine (DA) and norepinephrine (NE)), the DBH-TH mutant allele contains the TH coding sequence under the control of the endogenous DBH promoter region and restores TH expression in noradrenergic neurons. These DD mice may be useful in studying dopaminergic neurobiology (including neurotransmitters, addiction, feeding, learning and memory, catecholamines, and Parkinsonian phenotypes).

型号：GM-J#009666 -Cryorecovery

应用：These Ppargc1a (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha) conditional (floxed) mutant mice may be useful in generating conditional mutations for studying hepatic heme biosynthesis and porphyrias as well as neuromuscular junction physiology and muscular dystrophy.

型号：GM-J#009643 -Cryorecovery

应用：These transgenic mice express Cre recombinase under the control of the bovine LHB, luteinizing hormone beta polypeptide promoter. Cre recombinase expression is seen in mature pituitary gonadotropes, specifically in cells that produce luteinizing hormone beta. This strain represents an effective tool for generating tissue specific-targeted mutants that would be useful in the study of developmentally critical gene function in the pituitary.

型号：GM-J#009642 -Cryorecovery

应用：Cre recombinase expression is seen during development and in the adult in pituitary somatotropes. Weaker expression is detected in lactotropes. Cre expression is detected in the forelimb skin of embryos aged embryonic day 16.5-17.5 with weaker expression in adult kidney, ovary, and testis. This strain represents an effective tool for generating tissue specific-targeted mutants that would be useful for studying developmentally critical gene function in the anterior pituitary.

型号：GM-J#009616 -Cryorecovery

应用：These A930038C07Rik-Tg4-Cre mice express Cre recombinase under the control of the A930038C07Rik (RIKEN cDNA A930038C07 gene [also called epidermacan]) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues (including cortex, striatum, and cerebellum).

型号：GM-J#009615 -Cryorecovery

应用：These Cart-Tg1-Cre mice express Cre recombinase under the control of the Cartpt (CART prepropeptide) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues (including cortex, hippocampus, and cerebellum).

型号：GM-J#009614 -Cryorecovery

应用：These Wfs1-Tg2-CreERT2 mice express a tamoxifen-inducible Cre recombinase under the control of the mouse Wfs1 (Wolfram syndrome 1 homolog (human)) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues (including cortex, hippocampus, and cerebellum).

型号：GM-J#009613 -Cryorecovery

应用：These Scnn1a-Tg3-Cre mice express Cre recombinase under the control of the Scnn1a (sodium channel, nonvoltage-gated 1 alpha) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues (including cortex, thalamus, midbrain, and cerebellum).

型号：GM-J#009610 -Cryorecovery

应用：Mice hemizygous for the BAC LRRK2 transgene "overexpress" wildtype human leucine-rich repeat kinase 2 (LRRK2) gene directed by the human LRRK2 promoter/enhancer regions on the BAC transgene. These BAC LRRK2 mice (also called WT-OX mice) are a control strain for the BAC LRRK2R1441G Parkinson's disease strain (Stock No. 009604).

型号：GM-J#009609 -Cryorecovery

应用：These transgenic mice express the human LRRK2*G2019S, leucine-rich repeat kinase 2, mutant, and may be useful in studying Parkinson's disease.