型号：GM-J#012360 -Cryorecovery

应用：Erbb4-2A-CreERT2-D mice have both endogenous gene and CreERT2 fusion protein expression directed to Erbb4-expressing cells by the endogenous promoter/enhancer regions of the Erbb4 locus (v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)). When Erbb4-2A-CreERT2-D mice are bred with mice containing loxP-flanked sequences, tamoxifen-inducible Cre-mediated recombination will result in deletion of the floxed sequences in the Erbb4-expressing cells of the double mutant offspring.

型号：GM-J#012358 -Available

应用：Pvalb-T2A-Cre-D (Pvalb-2A-Cre-D) mice express Cre recombinase directed to Pvalb-expressing cells. Cre recombinase activity is observed in scattered interneuron populations in the cortex and hippocampus, as well as neuronal populations in other brain regions.

型号：GM-J#012352 -Cryorecovery

应用：The R26StopFLMEK1DD conditional allele is targeted to the Gt(ROSA)26Sor locus and has a loxP-flanked Neo-STOP cassette preventing transcription of the downstream bicistronic sequences (MEK1DD [a mutant form of rat MAPKK1 rendered constitutively active by two serine->aspartic acid substitutions (S218D/S222D) within the catalytic domain] and EGFP). These R26StopFLMEK1DD mice allow inducible constitutive activity of MAP Kinase signal transduction pathways that mediate various cellular activities, including gene expression, mitosis, differentiation, proliferation, cell survival, and cell cycle progression.

型号：GM-J#012343 -Cryorecovery

应用：The R26StopFLP110* conditional allele is targeted to the Gt(ROSA)26Sor locus and has a loxP-flanked Neo-STOP cassette preventing transcription of the phosphatidylinositol 3-kinase, catalytic, alpha polypeptide gene (Pik3ca or P110α) and EGFP. These R26StopFLP110* mice allow inducible expression of activated PIK3 heterodimer activity and may be useful in studying signaling cascades that control cell survival, growth, and proliferation, as well as differentiation, regeneration, hypertension and cancer.

型号：GM-J#012328 -Cryorecovery

应用：Tyr::CreERT2 mice have expression of CreERT2 fusion protein directed by mouse tyrosinase promoter/enhancer regions. When bred with mice containing loxP-flanked sequences, tamoxifen/4-hydroxytamoxifen-inducible Cre-mediated recombination will result in deletion of the floxed sequences in the Tyr-expressing cells of the offspring. These Tyr::CreERT2 mice may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in melanocytes/melanoblasts.

型号：GM-J#012265 -Cryorecovery

应用：The A30P mutation in this transgenic strain is associated with the development of familial Parkinson's disease. The onset of hind limb mobility problems occurs around 12 months of age (sometimes earlier), induced by a loss of motor neurons and associated with the formation of insoluble alpha synuclein aggregates. This strain may be useful in studies of Parkinson's disease.

型号：GM-J#012237 -Available

应用：These Ksp1.3/Cre transgenic mice express Cre recombinase under the control of the mouse cadherin 16 (Cdh16 or Ksp1.3) promoter. Cre recombinase expression is detected in epithelial cells of the developing kidney and genitourinary tract and in the renal tubules of adult mice. This mutant mouse strain may be useful in kidney-specific gene targeting and cell lineage studies.

型号：GM-J#011105 -Cryorecovery

应用：In this targeted mutation strain, the mouse Olig1 (oligodendrocyte transcription factor 1) locus drives expression of cre in Olig1-expressing cells of the central nervous system (CNS).

型号：GM-J#011104 -Available

应用：These transgenic mice have the mouse atonal homolog 1 (Drosophila) (Atoh1-cre or Math1-cre) regulatory sequences directing Cre recombinase expression primarily in precursors of granule cell neurons of the cerebellum and dorsal hindbrain/spinal cord in the dp1 domain

型号：GM-J#011103 -Cryorecovery

应用：In this targeted mutation strain, the mouse Olig2 (oligodendrocyte transcription factor 2) locus drives expression of cre and tva (an avian-specific retroviral receptor). This strain may be useful in studies of neurodevelopment.