型号：GM-J#012467 -Cryorecovery

应用：These BAC Lrrk2-G2019S mice express a mutant form of mouse leucine-rich repeat kinase 2 (Lrrk2-G2019S) associated with autosomal dominant, late-onset Parkinson's disease directed by the endogenous Lrrk2 promoter/enhancer regions on the BAC transgene. These mice have reduced striatal dopamine content and may be useful for studying Parkinson's disease pathogenesis and neurodegeneration elicited by the dominant toxic effects of mutant LRRK2-G2019S expression.

型号：GM-J#012466 -Cryorecovery

应用：These FLAG-Lrrk2-WT mice express a wild-type mouse leucine-rich repeat kinase 2 (Lrrk2) gene directed by its endogenous promoter/enhancer regions on a BAC transgene. These mice may be useful for studying normal function of LRRK2 function and the pathogenesis of Parkinson's disease.

型号：GM-J#012464 -Cryorecovery

应用：The Foxd1GCE allele expresses an eGFPCreERT2 fusion protein (EGFP and creERT2 fusion protein) from the Foxd1 promoter/enhancer elements. These mice may be useful for studying therapeutic strategies directly targeting pericyte differentiation in vivo and may productively impact fibrotic kidney disease.

型号：GM-J#012463 -Cryorecovery

应用：The Foxd1tm1(GFP/cre)Amc (or FoxD1GC) allele expresses an eGFPCre fusion protein from the Foxd1 promoter/enhancer elements. These mice may be useful for studying therapeutic strategies directly targeting pericyte differentiation in vivo and may productively impact fibrotic kidney disease.

型号：GM-J#012462 -Cryorecovery

应用：SF1-Cre transgenic mice have Cre recombinase expression detected in steroidogenic factor-1 (SF1)-positive neurons in the ventromedial hypothalamic nucleus as well as pituitary, gonad, and adrenal tissue. These mice may be useful for generating tissue specific-targeted mutants for studies of the subset of SF1-positive neurons, obesity, metabolic and energy homeostasis, and appetite control/satiety.

型号：GM-J#012453 -Cryorecovery

应用：Homozygous Lrrk2 knock-out mice may be useful for studying Parkinson's disease pathogenesis and neurodegeneration, as the deletion of Lrrk2 promotes the extension of neurites and decreases the accumulation of alpha-synuclein aggregates.

型号：GM-J#012452 -Cryorecovery

应用：Hoxb4-ENE-GFPCre transgenic mice have expression of a GFP/Cre fusion protein directed primarily to developing spinal cord and hindbrain by the mouse homeobox B4 early neuronal enhancer (ENE) region and heat shock protein 1B minimal promoter. These Hoxb4-ENE-GFPCre transgenic mice may be useful as a Cre-lox or fluorescent tool for the fate-mapping/lineage-tracing of Hoxb4-expressing neurons in the developing neural tube.

型号：GM-J#012450 -Cryorecovery

应用：These hemizygous transgenic mice carry a human synuclein (alpha-syn) gene, SNCA, regulated by a tetracycline operator (tetO). When mated to a mutant strain expressing tetracycline-controlled transactivator protein (tTA), expression of SNCA protein may be regulated with the tetracycline analog doxycycline (dox) in the double mutant offspring. These mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration elicited by the toxic effects of aggregation and somatic accumulation of SNCA.

型号：GM-J#012449 -Cryorecovery

应用：These hemizygous transgenic mice carry a human leucine-rich repeat kinase 2 gene, LRRK2, regulated by a tetracycline operator (tetO). When mated to a mutant strain expressing tetracycline-controlled transactivator protein (tTA), expression of LRRK2 protein may be regulated with the tetracycline analog doxycycline (dox) in the double mutant offspring. These mice may be useful for studying the Parkinson's disease pathogenesis and neurodegeneration.

型号：GM-J#012446 -Cryorecovery

应用：These transgenic mice express the mutant human LRRK2 sequence, 6055G->A transition (G2019S), and may be useful in studies of Parkinson's disease.